Methanone, [2-?[[8-?(dimethylamino)?octyl]?thio]?-?6-?(1-?methylethyl)?-?3-?pyridinyl]?-?2-?thienyl- [2-[[8-(Dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienylmethanone
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Y-29794, a novel orally non-peptide PPCE inhibitor, has shown to be able to prevent amyloid-like deposition in senescence-accelerated mice. Y-29794 exhibited potent inhibitory activity with an IC50 = 3.0 nM for both brain crude extract and partially purified enzyme fraction.
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