1-[(1α,3β,5Z,7E,22E,24R)-1,3,24-Trihydroxy-9,10-secochola-5,7,10(19),22-tetraen-24-yl]-cyclopropanecarboxylic Acid Butyl Ester (5Z,7E,22E)-(1S,3R,24R)-25-carbobutoxy-26,26-cyclo-9,10-seco-5,7,10(19),22-cholestatetraene-1,3,24-triol
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ZK159222 is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist with partial agonistic character. The antagonistic mechanism of ZK159222 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators.
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