ZK-261991

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Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2- methyl-2H-indazol-6-yl)- ZK261991

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ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2. The high efficacy, including tumour regression in established tumours, combined with its low toxicity recommends ZK 261991 for development as a drug for the therapy of solid tumours also in combination with other chemotherapeutics.

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