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1,2-propane-diol PROPYLENEGLYCOLTECHGRADE DL-1,2-Propanediol
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(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
Molar Mass | 76.09 |
Density | 1.036 g/mL at 25 °C (lit.) |
Melting Point | -60 °C (lit.) |
Boling Point | 187 °C (lit.) |
Specific Rotation(α) | n20/D 1.432 (lit.) |
Flash Point | 225°F |
JECFA Number | 925 |
Water Solubility | miscible |
Solubility | Miscible in water, acetone, ethyl acetate and chloroform, soluble in ether. It can be dissolved in many essential oils, but cannot be miscible with petroleum ether, paraffin and grease. |
Vapor Presure | 0.08 mm Hg ( 20 °C) |
Vapor Density | 2.62 (vs air) |
Appearance | Viscous Liquid |
Specific Gravity | 1.038 (20/20℃)1.036~1.040 |
Color | APHA: ≤10 |
Merck | 14,7855 |
BRN | 1340498 |
pKa | 14.49±0.20(Predicted) |
PH | 6-8 (100g/l, H2O, 20℃) |
Storage Condition | Store at +5°C to +30°C. |
Sensitive | Hygroscopic |
Explosive Limit | 2.4-17.4%(V) |
Refractive Index | n20/D 1.432(lit.) |
MDL | MFCD00064272 |
Physical and Chemical Properties | Colorless, viscous and stable water-absorbing liquid, almost tasteless and odorless. melting point -60 ℃ boiling point 187.3 ℃ relative density 1.0381 refractive index 1.4326 flash point 99 ℃ solubility, ethanol and a variety of organic solvents miscible. |
Use | Used as resin, plasticizer, surfactant, emulsifier and demulsifier of raw materials, can also be used as antifreeze and heat carrier |
Properties and applications | propylene glycol has good solubility, less toxicity and irritation, and is widely used as injections (such as intramuscular injections, solvents, extraction solvents and preservatives for non-injectable pharmaceutical preparations (e. G., oral liquids, Ophthalmic Preparations, ear preparations, dental preparations, rectovaginal preparations, transdermal preparations, etc.), is a better solvent than glycerol, can dissolve many substances such as corticosteroids (sex hormones), chloramphenicol, sulfonamides, barbiturates, reserpine, quinidine, dehydrocorticosterone acetate, tetrahydropalmatine sulfate, chlorambucil hydrochloride, vitamin A, vitamin D, many volatile oils, most alkaloids, and many local anesthetics. propylene glycol is similar to ethanol as a bacteriostatic agent, and the efficacy of inhibiting mold is similar to that of glycerol, which is slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer for aqueous film coating materials. The same amount of mixed liquid with water can delay the hydrolysis of some drugs and increase the stability of the preparation product. 15% ~ 30% propylene glycol solution, semi-solid preparations can be used as antibacterial preservatives, about 15% propylene glycol topical preparations can be used as humectants, 10% ~ 30% propylene glycol aerosol solvent, A 10% to 25% propylene glycol oral solution, 10% to 60% of an injection preparation, and 5% to 80% of a topical preparation are used as solvents and cosolvents. [stability and storage conditions] very stable at room temperature, but at high temperature (above 280 ° C) open placed to be oxidized; Mixed with 95% ethanol or water, With chemical stability; Can be autoclaved or filtered sterilization. Propylene glycol with hygroscopicity, should be placed in a cool and dry place, dark closed container storage. [incompatibility] Incompatibility with certain oxidants (such as potassium permanganate). This information was edited by Tong (2015-10-17). |
content analysis | a sample of 10 μL was injected into a gas chromatograph with a thermal conductivity detector. The column was a 1m x 6.35mm stainless steel column, the packing was polyethylene glycol 20m (Carbowax compound 20m) 4%, and the carrier was 40/60 mesh sieved Polytetrafluoroethylene (Chromosorb T) or similar material. The carrier gas was helium and the flow rate was 75ml/min. The sampling temperature is 240 ℃; The column temperature is 120~200 ℃, the temperature rise is 5 ℃/min; The final temperature is 250 ℃. Under the specified conditions, the retention time of propylene glycol is about 5.7min, and the retention time of three dipropylene glycol isomers are 8.2, 9.0 and 10.2min respectively. The area of all peaks was determined by any suitable method, and the percentage of propylene glycol area was calculated and converted to the mass percentage. |
toxicity | .FAO/WHO(2000):ADI 0~25mg/kg. LD5022 ~ 23.9mg/kg (mice, by mouth). GRAS(FDA,§ 184.1666,2000). |
usage limit | FAO/WHO(1984): Shannon cheese, 5g/kg (alone or in combination with other carriers and stabilizers) of the cream mixture. Japan (1998): raw noodles, raw fillings, cuttlefish smoked products is less than or equal to 2%; The skin of the jiaozi, roasted wheat, spring roll, Rawhide, etc. is less than or equal to 1.2%; Other food is less than or equal to 0.6%. GB 2760~96: cakes 3.0g/kg, gum FDA,§ 184.1666(2000): Alcoholic beverages 5%; Confectionery and frosting 24%; Frozen dairy 2.5%; Flavoring, flavoring agents, 97%; Fruit and nut products 5%; Other food 2.0%. |
Use | as a raw material for resins, plasticizers, surfactants, emulsifiers and demulsifiers, can also be used as antifreeze and heat carrier used as GC stationary liquid, solvent, antifreeze, plasticizer and dehydrating agent carrier solvent; Wetting agent; Humectant; Anti-caking agent; Antioxidant; Tissue improver; surfactants; Stabilizers; Thickeners; Dough conditioners; Emulsifiers; Flavoring agents; Excipients; Processing aids. GB 2760~96 is classified as a food processing aid. Mainly used in a variety of spices, pigments, preservatives, solvents, vanilla beans, roasted coffee grains, natural flavor extraction solvent. Candy, bread, packaging meat, cheese and other moisturizing, softener. Can also be used as noodles, core fillings of anti-mildew additives. In the milk to add 0.006%, can make the heating of the same flavor, made of white and shiny packaging tofu, fried volume expansion. propylene glycol is an intermediate of the fungicide difenoconazole. as a solvent, preservatives, pigments, antioxidants and other food additives insoluble in water can be dissolved in it, and then added into food, it has moisturizing and anti-freezing effects on food. China's regulations can be used for cakes, the maximum use of 3.0g/kg. propylene glycol is an important raw material for unsaturated polyester, epoxy resin and polyurethane resin, and the dosage in this area accounts for about 45% of the total consumption of propylene glycol. This unsaturated polyester is widely used in surface coatings and reinforced plastics. Propylene glycol has good viscosity and hygroscopicity and is non-toxic, so it is widely used as a hygroscopic agent, an anti-freezing agent, a lubricant and a solvent in the food, pharmaceutical and cosmetic industries. In the food industry, propylene glycol reacts with fatty acids to produce propylene glycol fatty acid esters, which are mainly used as food emulsifiers. Propylene glycol is an excellent solvent for condiments and pigments. Propylene glycol in the pharmaceutical industry is often used to produce all kinds of ointment, ointment solvent, softener and excipient, due to propylene glycol and all kinds of spices have good mutual solubility, so also used as a solvent and softener cosmetics, etc. Propylene glycol is also used as a solvent for tobacco moisturizers, mildewproofing agents, food processing equipment lubricants, and food marking inks. An aqueous solution of propylene glycol is an effective anti-freeze agent. as a drug carrier, granule drug agent. It can be used as a moisturizer, softener, solvent, etc. in cosmetics. Tobacco industry can be used as tobacco flavor, tobacco moisturizing agents, preservatives, etc. In the food industry, it is used as a solvent for flavor, food pigment, food packaging softener, food anti-adhesion agent, etc. Can also be used for the production of Unsaturated Polyester Resin, plastic plasticizer, dehydrating agent, surfactant, curing agent, Binder of raw materials. Can also be used in paints, pesticides, coatings and other industries aviation de-icing fluids, refrigerants and antifreeze agents, food and spices, fragrances, cosmetics and personal health care products, heat transfer fluids, hydraulic and brake fluids, paints and coatings, pet food/animal feed, pharmaceuticals, polyurethane, unsaturated polyester resin, etc. Solvents, organic synthesis, antifreeze, plasticizer, bactericide. Standard for gas chromatographic analysis. Gas chromatography stationary liquid (the highest temperature of 150 deg C, the solvent for chloroform), separation and analysis of alcohols, esters and ketones. |
production method | 1. Propylene oxide direct hydration method is a pressurized non-catalytic hydrolysis method. From propylene oxide and water in 150-160 ℃, 0.78-0.98MPa pressure, the direct hydration of the reaction product by evaporation, distillation, to get the finished product. 2. The Indirect hydration of propylene oxide is obtained by The Indirect hydration of propylene oxide and water with sulfuric acid as catalyst. 3. Direct catalytic oxidation of propylene. can be obtained from the hydrolysis of propylene oxide: CH3CHCH2 + H2O[H +]→ CH3CH(OH)CH2OH direct hydration of propylene oxide and water according to 1:15 molar ratio of ingredients, the reaction was carried out at 150~200 ℃ and 1.2 ~ 1.4MPa for 30min to obtain an aqueous solution containing 16% of propylene glycol, and the product was obtained by evaporative distillation. The catalytic hydrolysis reaction is carried out under the catalysis of sulfuric acid or hydrochloric acid. 10% ~ 15% of dilute sulfuric acid is added to 0.5% ~ 1.0% of propylene oxide aqueous solution, and the hydrolysis is carried out at 50~70 ℃; The hydrolysate is neutralized, concentrated under reduced pressure and refined to obtain a finished product. The preparation method is hydrolysis of propylene oxide to propylene glycol, which can be carried out in liquid phase. There are catalytic and non-catalytic methods in industry. The catalytic method is hydrolysis in the presence of 0.5% ~ 1% sulfuric acid at 50~70. No catalytic method in the high temperature pressure (150~300 ℃,980 ~ 2940kPa), the domestic production of this method. 1-chloro-2-propanol is produced by the reaction of propylene with chlorine water, which is obtained by hydrolysis with sodium carbonate solution. From the oxidation of propane to propylene oxide, and then hydrochloric acid hydrolysis obtained. |
category | flammable liquid |
toxicity grade | low toxicity |
Acute toxicity | oral-rat LD50: 20000 mg/kg; Oral-mouse LD50: 32000 mg/kg |
stimulation data | eyes-rabbit 100 mg mild |
explosive hazard characteristics | explosive when mixed with air |
flammability hazard characteristics | flammability; Combustion stimulus smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying |
extinguishing agent | dry powder, foam, sand, water |
spontaneous combustion temperature | 779 ° F. |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging:
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage:
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery:
Usually within3-5 working days after full payment.
transport:
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.
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