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Methilonin Thiomedon Methionine, amorphous
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Product introduction:
properties | DL-methionine is a white flake crystal or crystalline powder. Special odor. The taste was slightly sweet. Melting point 281 degrees (decomposition). 10% pH of the aqueous solution 5.6-6.1. No optical rotation. Stable to heat and air. Unstable to strong acids, can lead to demethylation. Soluble in water (3.3g/100ml,25 degrees), dilute acid and dilute solution. Very difficult to dissolve in ethanol, almost insoluble in ether. |
Use | DL-methionine may be used as a nutritional supplement. The physiological effect is the same as that of L-type methionine, but the L-type is low in price (L-type is produced by DL-type), so DL-methionine is generally used. In oats, rye, rice, corn, wheat, peanut flour, soybeans, potatoes, spinach and other plant-based foods to improve amino acid balance. applicable to the prevention and treatment of liver disease and arsenic or benzene poisoning, can also be used for the treatment of dysentery and chronic infectious diseases caused by protein deficiency after malnutrition This product is a feed Nutrition Fortifier. Lack of methionine in livestock and poultry will cause dysplasia, weight loss, liver and kidney function, muscle atrophy, fur deterioration and so on. Feed added 1kg methionine, equivalent to the nutritional value of 50kg fish meal. The general amount of feed is 0,05%-0.2%. nutritional supplements. The physiological effect is the same as that of L-type methionine, but the L-type is low in price (L-type is produced by DL-type), so DL-methionine is generally used. In oats, rye, rice, corn, wheat, peanut flour, soybeans, potatoes, spinach and other plant-based food belonging to the restriction of amino acids. Added to the above foods to improve the amino acid balance. Requirements vary with cystine intake. The requirement for an adult male is 1.1g/d. Sea urchin and methionine related, sea urchin sweet and glycine, alanine related, bitter and valine related, flavor and glutamic acid and so on, so these amino acids can be formulated into flavoring agent. Still used for amino acid infusion, comprehensive amino acid preparation. According to China GB 2760-86 regulations can be used as spices. The content of commercial methionine is more than or equal to 98.5%, which is one of the essential amino acids for the growth of livestock and animals, and is the "skeleton" amino acid of biosynthetic protein, which has a strong regulatory effect on the metabolism of animals, widely used in medicine, food, feed and cosmetics and other fields. Which in medicine, can be used as the main component of amino acid infusion and compound amino acids, can also be used for the synthesis of medicinal vitamins, the use of its anti-fatty liver, can be used for the production of liver preparations; In food, for food amino acid fortification and processing of food and health products, can be used as nutritional supplements, due to special odor, so only for fish cake products; In the feed industry, the largest amount of methionine, used as feed Nutrition Fortifier, make up the balance of amino acids in feed additives, amino acid nutrition feed additives in varieties, methionine 60%, lysine accounted for 30%, other amino acids accounted for about 10%. used as a Biochemical reagent biochemical studies; Used in the culture of mammalian and insect cells with mixed isomers |
range of use | adult male requirement: 1G/d. Can be safely used in food. It accounts for 3.1% of the total protein in food. Not for infants and young children food. |
principle of action | DL-methionine is one of the essential amino acids for human body, and deficiency can cause liver and kidney disorders. It is especially important for the protection of liver function. Can promote hair, nail growth, and detoxification and enhance muscle activity and other effects. |
content analysis | a sample of approximately mg was accurately weighed and transferred into a stopcock flask. Add 100ml of water, 5g of Dipotassium hydrogen phosphate, 2g of potassium dihydrogen phosphate and 2g of potassium iodide, and mix well until dissolved. Then 50ml of 0.1mol/L iodine solution was accurately measured, and the flask was closed and mixed. After standing for 30min, the excess iodine was titrated with 0.1mol/L sodium thiosulfate. At the same time, the blank test was carried out and the necessary correction was made. Each MIM 0.1mol/L iodine solution corresponds to 7.461mg of DL-methionine (C5HllNO2S). |
toxicity | L-type: LD5029mmol/kg (rat, intraperitoneal injection);D-type: LD5035mmol/kg (rat, intraperitoneal injection). Safe for use in food (FDA,§ 172.320,2000). |
usage limit | FDA,§ 172.320(2000):(1) not for infant food;(2) it accounts for 3.1% of the total protein in food. FEMA: same as "01115, isoleucine". |
production method | methionine can be prepared by extraction, but there are the following methods in industry: 1. Rhone-Planck process 2. The consumption quota of DL-methionine process raw materials in dpoga: acrolein 480kg/t, methyl mercaptan 400kg/t, sodium cyanide 420kg/t. methionine of the D-configuration and the L-configuration have the same physiological action, and DL-type is often used, so it is advantageous to produce it synthetically. It is generally prepared by reacting acrolein with methyl mercaptan. A synthesis method using an acrylic aldehyde as a raw material is generally used. The condensation of Propylene aldehyde and methyl mercaptan in the presence of formic acid and copper acetate produces 3-methylthiopropionaldehyde. Then mixed with sodium cyanide and ammonium bicarbonate solution. The reaction at 90 °c gave methylthioethyl hydantoin. Without separation and purification, it can be heated with 28% sodium hydroxide solution to 180 C, hydrolysis to form sodium methionine. The final methionine was obtained by neutralization with hydrochloric acid. Each ton of product consumption of acrylic aldehyde 480kg, methyl mercaptan 400kg, sodium cyanide 420kg |
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