Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Molar Mass	172.2
Density	1.08
Melting Point	164-166°C(lit.)
Boling Point	400.5±47.0 °C(Predicted)
Water Solubility	7.5 g/L at 25 ºC
Solubility	Soluble in acetone, glycerin, hydrochloric acid, boiling water and caustic solution, slightly soluble in water, almost insoluble in chloroform, ether, petroleum ether and benzene.
Vapor Presure	0.00001 hPa (70 °C)
Appearance	White particles or powdered crystals
Color	white to faintly beige
Odor	Odorless
Maximum wavelength(λmax)	257nm(H2O)(lit.)
Merck	14,8925
BRN	511852
pKa	pKa 10.65(H2Ot = 25.0±0.5I = 0.2) (Uncertain)
PH	5.8-6.1 (5g/l, H2O, 20℃)
Storage Condition	2-8°C
Sensitive	Easily absorbing moisture
Refractive Index	1.6490 (estimate)
MDL	MFCD00007939
Physical and Chemical Properties	Characteristics of white particles or powder Crystal, odorless. The taste was slightly bitter. Melting Point: 165~166 ℃ relative density: 1.08g/cm3 solubility: slightly soluble in cold water, ethanol, methanol, ether and acetone, soluble in boiling water, glycerin, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.
Use	Used in the pharmaceutical industry, is the main raw material for the synthesis of sulfonamides

 Uses and synthesis methods

product features

Sulfonamide is also called p-aminobenzene sulfonamide, sulfonamide, p-aniline sulfonamide, p-sulfonamide aniline. The precipitated from the ethanol aqueous solution is a white leaf-like crystal or crystalline powder, odorless, slightly bitter and then sweet, and changes color when exposed to light. Relative molecular mass 172.22. Relative density 1.08. Melting point 165~166 ℃. Insoluble in benzene, ether, chloroform, soluble in water (g/l): 2.6 at 10 ℃, 7.5 at 25 ℃, 17.0 at 40 ℃, 40.0 at 60 ℃, 477 at 100 ℃, soluble in ethanol, 1g per 37ml of ethanol, 1g per 5ml of acetone, soluble in glycerin, propylene glycol, soluble in hydrochloric acid and sodium hydroxide (potassium) solution, sulfa amine aqueous solution litmus test paper is neutral, pH of 0.5% aqueous solution = 5.8~6.1. The color becomes darker under light. A large amount of sulfanilamide in humans can cause nausea, vomiting, diarrhea, affect the liver and kidneys, and can also cause tinnitus, dizziness, headache, and even various neurological symptoms until death. The dog's oral LD50 2000mg/kg.

[pharmacodynamics] the mechanism of action is to interfere with the synthesis of nucleic acid required by pathogenic microorganisms, so that bacteria lack nutrition and stop growth, development and reproduction. It has inhibitory effect on hemolytic streptococcus, staphylococcus and meningococcus.

[Pharmacokinetics] Oral administration is easy to be absorbed from the gastrointestinal tract and is widely distributed in the body. It can penetrate the blood-brain barrier into the brain tissue and the placental barrier into the fetus. Excretion is faster, mainly metabolites are excreted from the kidneys.

[clinical application] is mainly used for traumatic infection caused by hemolytic streptococcus and staphylococcus, and local wound infection.

[use] this product is a sulfonamide drug poisoning is low, can be used for infants, pregnant women, women and menstruation, but should not be taken in large quantities. It is effective for hemolytic streptococcal infections (erysipelas, puerperal fever, tonsillitis), urinary tract infections (gonorrhea), etc.; it is also an intermediate for the synthesis of other sulfa drugs (such as sulfamidine, sulfamethazine and sulfamethoxazine, etc.).

chemical properties

white particles or powdered crystals, odorless. The taste is slightly bitter. Slightly soluble in cold water, ethanol, methanol, ether and acetone, soluble in boiling water, glycerin, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.

use

1. It is used in the pharmaceutical industry and is the main raw material for the synthesis of sulfonamides

2. Used as a reagent for the determination of nitrite, also used in the pharmaceutical industry

3. Intermediates used in the synthesis of other sulfa drugs, occasionally used for wound disinfection and sterilization

4. p-aminobenzenesulfonamide is an intermediate of the herbicide sulfa and an intermediate of pharmaceutical sulfa.

5. this product is an important intermediate of sulfonamides.

6, veterinary drugs, external anti-inflammatory drugs, used for analysis and detection.

7. The antibacterial spectrum is broad, and it has antibacterial effects on Gram-positive and negative bacteria such as hemolytic streptococcus, Neisseria meningitidis, Staphylococcus. This product is topical and can be absorbed by self-wound surface. It is used for traumatic infection of hemolytic streptococcus and staphylococcus. It can also be used for rapid hemostasis of wounds.

production method

1, prepared by chlorosulfonation, amination, hydrolysis and neutralization of acetanilide. Raw material consumption quota: acetanilide (99%)1032 kg/t, chlorosulfonic acid (96%)4521 kg/t, liquid ammonia (99.8%)535 kg/t, liquid alkali (30%)863 kg/t.

2. the preparation methods are as follows.

(1) Use acetanilide as raw material

The reaction of acetanilide and chlorosulfonic acid at 40~50 ℃, then cooling, slowly adding water for acid decomposition, while precipitation, drying and filtering to obtain acetaminobenzenesulfonyl chloride, and then ammoniation, ammoniation temperature Control at 40~45 ℃, and then hydrolyze and acidify.

(2) mixed diphenylurea method

Monophenylurea and diphenylurea (called mixed urea) are condensed from aniline and urea, which are then obtained by chlorosulfonation, amination, hydrolysis, and acid analysis. The reaction process is as follows.

① condensation firstly, aniline hydrochloride and urea are condensed and reacted at a temperature of 101~110 ℃ for 3~4h to obtain mixed diphenylurea.

② chlorosulfonation Press chlorosulfonic acid into a sulfonation pot, cool and stir, when the temperature drops below 10 ℃, evenly add mixed phenylurea under stirring condition, make the reaction temperature gradually rise, finish the feeding, keep the temperature at 46~50 ℃ for 2 hours, cool to below 10 ℃, add water for acid decomposition. Control the decomposition temperature not to exceed 15 ℃, continue to stir for 20min after adding water, and then precipitate and wash with water to obtain mixed phenylurea sulfonyl chloride.

③ ammoniated 2% ammonia water is put into an ammoniating pot, cooled to 25 ℃, mixed phenylurea sulfonyl chloride is put into stirring, the temperature is controlled to 40 ℃, and the heat preservation reaction is carried out for 3 hours to obtain ammoniated liquid.

④ hydrolysis, neutralization, raise the ammonia solution to above 90 ℃, add 3% lye, continue to raise the temperature to 108~112 ℃, carry out hydrolysis for 5 hours, move into a neutralization crystallization pot, add hydrochloric acid to neutralize crystallization, cool the crystallization solution to 20 ℃, crystallize, filter, wash with water and dry to obtain the finished product.

category

Pesticides

toxicity classification

Poisoning

acute toxicity

oral-rat LD50: 3900 mg/kg; oral-mouse LD50: 3000 mg/kg

flammability hazard characteristics

Combustible in open flames, high temperatures, and strong oxidants; combustion emits nitrogen oxides and sulfur oxides to stimulate smoke

storage and transportation features

The packaging is complete, light and light; the warehouse is ventilated, away from open flames, high temperature, and stored separately from the oxidant

fire extinguishing agent

foam, carbon dioxide, dry powder, sand, 1211

Reference Information

Product characteristics	sulfonamides, also known as sulfanilamide, sulfonamide, P-aniline sulfonamide, P-sulfonamide aniline. From the ethanol solution in the precipitation of white leaf-like crystal or crystalline powder, odorless, taste first slightly bitter and then sweet, light discoloration. Relative molecular mass 172.22. The relative density was 1.08. The melting point was 165-166 °c. Insoluble in benzene, ether, chloroform, soluble in water (g/l): 10 ℃ 2.6, 25 ℃ 7.5, 40 ℃ 17.0, 60 ℃ 40.0, 100 ° C 477, also soluble in ethanol, ethanol soluble 1g per, acetone soluble 1g per 5ml, soluble in glycerol, propylene glycol, soluble in hydrochloric acid and sodium hydroxide (potassium) solution, the litmus paper of sulfanilamide aqueous solution is neutral, and the pH of 0.5% aqueous solution is 5.8~6.1. Color darkened under light. Humans take a large number of sulfonamides, can cause Nausea, Vomit, Diarrhea, the liver, kidney effects, but also cause tinnitus, vertigo, Head Pain, and even a variety of neurological symptoms, until death. Dog oral LD50 2000mg/kg. [pharmacodynamics] The mechanism of action is to interfere with the synthesis of nucleic acids required by pathogenic microorganisms, so that the bacteria lack nutrition and stop growth, development and reproduction. The hemolytic Streptococcus, Staphylococcus and meningococcus have inhibition and killing effect. [pharmacokinetics] Oral easily absorbed from the gastrointestinal tract, widely distributed in the body, can penetrate the blood-brain barrier into the brain tissue, and can penetrate the placental barrier into the fetus. Rapid excretion, mainly metabolites from the kidney. [clinical application] it is mainly used for traumatic infection caused by hemolytic Streptococcus and Staphylococcus, and local wound infection. [use] This product is a low toxicity of sulfonamides, infants, pregnant women, maternal and menstrual period can be used, but not a lot of use. It is effective for hemolytic streptococcal infection (erysipelas, puerperal fever, tonsillitis), urinary tract infection (gonorrhea), etc. It is also an intermediate for synthesizing other sulfonamides (such as sulfamidine, sulfamethazine and sulfamethoxazine)..
Chemical properties	white particles or powder crystals, odorless. The taste was slightly bitter. Slightly soluble in cold water, ethanol, methanol, ether and acetone, soluble in boiling water, glycerol, hydrochloric acid, potassium hydroxide and sodium hydroxide solution, insoluble in chloroform, ether, benzene, petroleum ether.
Use	used in the pharmaceutical industry, is the main raw material of the synthesis of sulfonamides used as a reagent for the determination of nitrite, also used in the pharmaceutical industry for the synthesis of other sulfa drug intermediates, even for wound Disinfection sterilization sulfanilamide is an intermediate of the herbicide sulfasalazine, is also an intermediate of the pharmaceutical sulfonamides. This product is an important intermediate of sulfonamides. veterinary drug, external anti-inflammatory drug, used for analysis and detection. The antibacterial spectrum is broad, and it has antibacterial effect on Gram-positive and negative bacteria such as hemolytic Streptococcus, Neisseria meningitidis and Staphylococcus. This product is a local medication, self-absorption of part of the surface. For hemolytic Streptococcus and Staphylococcus aureus and other traumatic infections. It can also be used for rapid hemostasis of wounds.
production method	from acetanilide by chlorosulfonation, amination, hydrolysis, neutralization. Raw material consumption quota: Acetanilide (99%)1032kg/t, chlorosulfonic acid (96%)4521kg/t, liquid ammonia (99.8%)535kg/t, liquid alkali (30%)863kg/t. There are several preparation methods. (1) with acetanilide as raw material, acetanilide and chlorosulfonic acid are reacted at 40~50 ℃, then cooled, slowly added into water for acid decomposition, and at the same time precipitation, drying and filtering to get acetaminophen benzene sulfonyl chloride, then ammoniation is carried out, and the ammoniation temperature is controlled at 40 to 45 ° C., followed by hydrolysis and acidification. (2) mixed diphenylurea method from aniline, urea condensation of monophenylurea and diphenylurea (known as mixed urea), and then chlorosulfonation, amination, hydrolysis, acid analysis obtained. The reaction process was as follows. (1) condensation aniline hydrochloride is condensed with urea and reacted at a temperature of 101-110 ° C. For 3-4H to give mixed diphenylurea. ② chlorosulfonation pressure chlorosulfonic acid into the sulfonation Pan, cooling and stirring, when the temperature dropped to below 10 ℃, mixing phenylurea is added uniformly under stirring, the reaction temperature gradually increased, the mixture was stirred at 46-50 °c for 2H, cooled to below 10 °c, and water was added for acid decomposition. The decomposition temperature was controlled not to exceed 15 ° C. After adding water, stirring was continued for 20min, followed by precipitation and washing with water to obtain mixed phenylurea sulfonyl chloride. (3) 2% ammonia water was put into an ammoniating Pan and cooled to 25 ° C., mixed phenylurea sulfonyl chloride was added under stirring, the temperature was controlled at 40 ° C., and the reaction was maintained for 3H to obtain an ammoniating solution. ④ hydrolysis and neutralization the ammoniation solution was heated to above 90 ℃, 3% alkali solution was added, and the temperature was continued to rise to 108~112 ℃, hydrolysis was carried out for 5H, transferred into neutralization crystallization pan, and hydrochloric acid was added to neutralize the crystallization, the crystallization solution was cooled to 20 ° C., crystallized, filtered, washed with water and dried to obtain a finished product.
category	pesticide
toxicity grade	poisoning
Acute toxicity	oral-rat LD50: 3900 mg/kg; Oral-mouse LD50: 3000 mg/kg
flammability hazard characteristics	flammable in open flame, high temperature, strong oxidant; combustion emissions of nitrogen oxides and sulfur oxides stimulate smoke
storage and transportation characteristics	The package is complete, light, light; The warehouse is ventilated, away from open flame, high temperature, separate from oxidant
fire extinguishing agent	foam, carbon dioxide, dry powder, sand, 1211

 

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.