Asiaticoside 16830-15-2

Details:

16830-15-2 - Names and Identifiers

Name	Asiaticoside
Synonyms	Snow Grass Pure Dew Ba 2742 CENTELASE Centelase NSC 166062 CCRIS 8995 Asiaticosid BRN 0078195 asiaticosid ASIATICOSIDE Asiaticoside Dermatologico dermatologico blastoestimulina Blastoestimulina Gotu Kola Extract 4-17-00-03627 (Beilstein Handbook Reference) ranosyl-(1-4)-o-beta-d-glucopyranosyl-(1-6)-o-beta-d-glucopyranosylester 2-alpha,3-beta,23-trihydroxy-urs-12-en-28-oicacio-6-deoxy-alpha-l-mannopy (O-alpha-L-Rhamnopyranoxyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl)-2alpha,3beta,23-trihydroxy-12-ursen-28-oat O-6-Desoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl 2alpha,3beta,23-trihydroxy-12-ursen-28-at 2alpha,3beta,23-Trihydroxy-urs-12-en-28-saeure(O-alpha-L-rhamnopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-O-beta-D-glucopyranosyl)ester O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha)-2,3,23-trihydroxyurs-12-en-28-oate Urs-12-en-28-oic acid, 2-alpha,3-beta,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-o-beta-D-glucopyranosyl-(1-6)-o-beta-D-glucopyranosyl ester Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (2alpha,3beta,4alpha)-
CAS	16830-15-2
EINECS	240-851-7
InChI	InChI=1/C48H78O16/c1-22-12-17-48(19-18-46(7)25(30(48)23(22)2)10-11-29-45(6)15-9-14-44(4,5)28(45)13-16-47(29,46)8)43(58)64-42-37(56)34(53)32(51)27(62-42)21-59-40-38(57)35(54)39(26(20-49)61-40)63-41-36(55)33(52)31(50)24(3)60-41/h10,22-24,26-42,49-57H,9,11-21H2,1-8H3/t22-,23+,24+,26-,27-,28+,29-,30+,31+,32-,33-,34+,35-,36-,37-,38-,39-,40-,41+,42+,45+,46-,47-,48+/m1/s1

16830-15-2 - Physico-chemical Properties

Molecular Formula	C48H78O19
Molar Mass	959.12
Density	1.44±0.1 g/cm3(Predicted)
Melting Point	235-238°C
Boling Point	1017.5±65.0 °C(Predicted)
Specific Rotation(α)	D20 -14° (alc)
Water Solubility	99mg/L
Solubility	DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)
Vapor Presure	0.001Pa at 160℃
Appearance	Pale yellow crystal
Color	Crystals
pKa	12.50±0.70(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Easily absorbing moisture
Refractive Index	1.606
MDL	MFCD06642601
Physical and Chemical Properties	White crystalline powder, soluble in water, ethanol, insoluble in ether, chloroform, from Centella asiatica.
Use	Promote wound healing, stimulate the growth of granulation, treatment of various skin diseases

16830-15-2 - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
UN IDs	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS	YU9625000
FLUKA BRAND F CODES	1-10
HS Code	29389090

16830-15-2 - Reference

Reference  Show more

1. Huang Yiqi, Sun Yajing, Fang Li, et al. Effects of asiaticoside on Proliferation and Collagen Secretion of Human Fibr...

16830-15-2 - Efficacy and role

Open Data Unverified Data

Centella asiatica pure Dew is the main component of Centella asiatica extract, its cold, bitter taste, pungent, return to the liver, spleen, kidney, with heat and dampness, detoxification swelling, hemostasis and pain, the effect of calming the nerves. Commonly used in the treatment of summer heat, sore throat, dysentery, damp-heat jaundice, blood-heat bleeding, boils swelling, bruises and other diseases.

 

16830-15-2 - Reference Information

plant source:	asiatica
LogP	0.44 at 22℃
pharmacological effects	century asiatica is the dry whole grass or root whole grass of the Umbelliferae plant (Centellaasiatica(L)Urban), also known as Lei Gonggen, horseshoe grass, which can be harvested all the year round and is rich in resources. It has grown in Southeast Asia, Australia, South Africa and tropical Central Africa and has a long history of application in the field of medicine in many countries. The asiatica is cold in nature and bitter in taste. It has the effects of clearing heat and dampness, detoxification and detumescence. It is mainly used for damp-heat jaundice, heatstroke diarrhea, carbuncle swelling poison, and bruises. asiaticoside (Asiaticoside) belongs to pentacyclic triterpenoids, which has many pharmacological effects such as anti-ulcer, promoting wound healing, anti-tumor, anti-inflammatory, immune regulation, etc. At present, it is mainly used to treat scleroderma and skin trauma and burns.
mechanism of action	asiaticoside can act on the nucleus of fibroblasts, reducing the mitotic phase and reducing or missing the nucleolus. With the increase of drug concentration, intracellular DNA synthesis is reduced, cell growth is in an inhibited state, and the inhibition rate can reach up to 73%, suggesting that the mechanism of asiaticoside is to block the proliferation of fibroblasts, so as to reduce the synthesis of collagen and prevent scar hyperplasia.
application	asiaticoside (Asiaticoside) is the main component of asiaticoside. the mixture of asiaticoside a and asiaticoside B has pharmacological effects such as promoting wound healing, anti-wrinkle, anti-inflammatory, anti-depression and promoting intelligence. Comparing the pharmacological effects of asiaticoside on promoting wound healing and treating scars, it can be found that the anti-inflammatory, anti-depressant, and intelligence-promoting pharmacological effects of asiaticoside A and asiaticoside B may play a major role.
preparation method	weigh 500g of crushed snow grass powder, soak it in 2500ml of 75% ethanol aqueous solution, extract it by ultrasonic wave for 4 times at 50 ℃ for 1 hour each time, and concentrate the filtrate under reduced pressure to obtain 20.5g of extract. Dissolve the extract with 200ml of water, and extract it for 3 times with petroleum ether of the equal volume of the extract aqueous solution, the lower phase aqueous solution is then extracted 4 times with equal volume of ethyl acetate, and the lower phase aqueous solution is collected. The volume ratio of n-butanol and ethyl acetate of the same volume of the pooled lower phase aqueous solution is 1: 1 mixed solvent for extraction for 3 times, the upper phase extract is combined, the activated carbon decolorized extract is used, and the decolorized extract is concentrated under reduced pressure to obtain the total glucoside of centella asiatica 7.3g; Add 10 times the amount of methanol to dissolve the total glucoside of centella asiatica, filter, concentrate the filtrate, and recrystallize with an ethanol aqueous solution with a mass concentration of 90% at room temperature, the purity is 90% and the yield is 0.66%.
use	promote wound healing, stimulate granulation growth, treat various skin diseases promote wound healing, stimulate granulation growth, treat various skin diseases.
category	toxic substances
flammability hazard characteristics	combustible; combustion produces stimulating smoke
storage and transportation characteristics	ventilation and low temperature drying
fire extinguishing agent	dry powder, foam, sand, carbon dioxide, mist water

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

introduce

Gotu Kola grows in tropical swampy areas. Slender stolon stems, green to red-green in color, connect plants to each other. It has a long stalk, a green, rounded tip, a smooth texture, and palmate reticular veins. The leaves grow on a peripheral petiole, about 2 cm (0.79 in). The rootstock consists of a rhizomes that grow vertically downwards. They are cream colored and covered with root hair.

Asiaticoside is a triterpenoid glycoside from the plant Asiaticoside and is commonly used in wounds

Recovery. This activity is the result of stimulating collagen and glycosaminoglycan synthesis. this

Glycosides were also found to be active against herpes simplex viruses 1 and 2 and mycobacterium tuberculosis. Neuroprotective agent.

function

1, diuretic swelling.

Refresh your mind.

3. It has the functions of nourishing, anti-inflammatory, healing wounds or ulcers, invigorating and calming.

4. Cure leprosy and ulcers.

5. Wave effect on blood purification and immunity.

6. Reduce blood pressure and treat liver disease.

7. Antibacterial effect.

8. Can make the skin soft, help to improve the skin flabby phenomenon.

9. Helps promote collagen formation in dermis.

10. Heal damaged tissues and tighten skin, prevent eczema, detumescence and detoxification, and remove abscesses.

application

1. Used in cosmetic field.

2. Used in food field.

3. Used in pharmaceutical field.

4. Used as feed additive

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.