Catalpol

Details:

Name	Catalpol
Synonyms	CATAPOL Catalpol CATALPOL Catalpinoside catalpinoside CATALPOL HPLC GRADE ,6-beta,6a-alpha))- De(p-hydroxybenzoyl)catalposide de(p-hydroxybenzoyl)catalposide des-p-hydroxybenzoyl-catalposid Catalposide, des-p-hydroxybenzoyl- beta-d-glucopyranoside,1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl) oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl,(1as-(1a-alpha,1b-beta,2-beta,5a-beta 6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl hexopyranoside (1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl beta-D-glucopyranoside (1AS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl-beta-D-glucopyranoside beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1aalpha,1bbeta,2beta,5abeta,6beta,6aalpha))- beta-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy- 1a-(hydroxymethyl)oxireno(4,5)cyclopenta(1,2-c)pyran-2-yl, (1aS-(1a-alpha,1b-beta,2-beta,5a-beta,6-beta,6a-alpha))-
CAS	2415-24-9
EINECS	219-324-0
InChI	InChI=1/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2
InChIKey	LHDWRKICQLTVDL-CLLMHHLUSA-N

2415-24-9 - Physico-chemical Properties

Molecular Formula	C15H22O10
Molar Mass	362.33
Density	1.72±0.1 g/cm3(Predicted)
Melting Point	203-205°C
Boling Point	675.6±55.0 °C(Predicted)
Specific Rotation(α)	-122 (EtOH aq.)
Flash Point	362.4°C
Solubility	Easily soluble in water, methanol, ethanol, slightly soluble in ethyl acetate.
Vapor Presure	3.77E-21mmHg at 25°C
Appearance	White powder
Color	White to Off-White
pKa	12.79±0.70(Predicted)
Storage Condition	Inert atmosphere,Store in freezer, under -20°C
Refractive Index	1.679
MDL	MFCD11111524
Physical and Chemical Properties	Soluble in water, methanol, ethanol, ethyl acetate-soluble. Fresh or dried root tubers from the plant rehmannia glutinosa of the scrophulaceae
In vitro study	Catalpol (0.1 μg/mL; for 3 days) can induce neuronal differentiation in PC12 cells through activation of the intracellular signal transduction pathway, and promote neurite length.

2415-24-9 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	LZ5776816
HS Code	29389090

2415-24-9 - Introduction

Pharmacological effects: anti-cancer, neuroprotection, anti-inflammatory, diuretic, hypoglycemic and anti-hepatitis virus effects.

 

2415-24-9 - Reference Information

pharmacological action	catalpol is a iridoid glycoside compound that reduces blood sugar and has delayed effect and alleviates diarrhea. it is the main component of radix rehmanniae of Scrophulariaceae. In addition, catalpol also has anti-cerebral ischemia injury, anti-senile dementia, anti-cancer, anti-hepatitis virus, antispasmodic, inhibit capillary permeability and other activities.
biological activity	Catalpol (Catalpinoside) is an iris glycoside found in Rehmannia glutinosa, which has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasm, antioxidant and anti-HBV effects.
Animal Model:	C57BL/6 mice treated with renal ischemia/reperfusion surgery
Dosage:	25 mg/kg, 50 mg/kg and 100 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.
use	used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-cancer, neuroprotection, anti-inflammatory, diuretic, hypoglycemic and anti-hepatitis virus effects. The main function is to stimulate the production of adrenal cortex hormones, thereby increasing the production of hormones. Catalpol also has anti-inflammatory activity and has been shown to increase the production of male hormones produced by the adrenal glands, resulting in an enlarged muscle mass.
Production method	It is prepared by reacting diethyl ketone with 1-aminovinyl methyl ketone.

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9.How do you treat quality complaint

First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.