Myricitrin17912-87-7

Details:

17912-87-7 - Names and Identifiers

Name	3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-benzopyran-4-one
Synonyms	MYRICITRIN myricitrin 17912-87-7 Myricetrin CANNABISCITRIN MYRICETIN-3-RHAMNOSIDE MYRICETIN-3-O-RHAMNOSIDE MYRICETIN-3-O-RHAVINOSIDE 5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl 6-deoxyhexopyranoside 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl 6-deoxy-a-L-mannopyranoside 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl-6-deoxy-alpha-L-mannopyranoside 5,7-Dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-benzopyran-4-one 6-Désoxy-alpha-L-mannopyranoside de 5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphényl)-4H-chromén-3-yle 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-benzopyran-4-one 4H-1-benzopyran-4-one, 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)- 5,7-dihydroxy-3-((2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2-(3,4,5-trihydroxy-phenyl)-1-benzopyran-4-one 5,7-Dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-on 5,7-Dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}-2-(3,4,5-trihydroxyphényl)-4H-chromén-4-one 5,7-Dihydroxy-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
CAS	17912-87-7
EINECS	241-856-7
InChI	InChI=1/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-27,29-30H,1H3

17912-87-7 - Physico-chemical Properties

Molecular Formula	C21H20O12
Molar Mass	464.38
Density	1.88±0.1 g/cm3(Predicted)
Melting Point	197°C(lit.)
Boling Point	896.6±65.0 °C(Predicted)
Specific Rotation(α)	-138.6 (c, 0.5 in MeOH)
Flash Point	315.6°C
JECFA Number	2207
Solubility	Soluble in DMSO, hot methanol, slightly soluble in water and absolute ethanol.
Vapor Presure	1.44E-34mmHg at 25°C
Appearance	pale yellow flake crystal
Color	Light yellow to Yellow to Orange
pKa	6.16±0.40(Predicted)
Storage Condition	-20°C
Refractive Index	1.805
MDL	MFCD00016930
Physical and Chemical Properties	Yellow crystalline powder, soluble in water, soluble in methanol, ethanol, glacial acetic acid, from storage, Bayberry Bark, bayberry leaves.
In vitro study	Myricitrin, a compound isolated from the bark of the waxberry Myrica rubra, exerts analgesic effects. In rodent models of chemical and mechanical pain, Myricitrin produces significant analgesia by preventing activation of protein kinase C (PKC) α and PKC ε by phorbol ester (PMA). Another study demonstrated that the opening of voltage and small conductance calcium-gated K (+) channels and the reduction of calcium influx are responsible for the analgesic effect of myricitrin. Myricitrin also activates caspase-3 and MAPK signaling pathways by inhibiting p53 gene expression, and change the expression pattern of pro-apoptotic and anti-apoptotic genes and reduce the apoptosis induced by H 2 O 2 in vascular endothelial cells.
In vivo study	In mice, myricitrin (I. p. 10 mg/kg or 30 mg/kg) blocked apomorphine-induced stereotyped behavior and climbing and increased hindlimb withdrawal time (HRT).

17912-87-7 - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29389090

17912-87-7 - Reference

Reference  Show more

1. Guo Shuangshuang Zheng Fangfang Ke Cong Xue et al. Analysis of Enzymatic Properties of α-L-rhamnosidase from Pediococ...

17912-87-7 - Nature

Open Data Verified Data

The melting point of myricetin containing one crystal of water of crystallization is 194 to 197 °c.

Last Update：2024-01-02 23:10:35

17912-87-7 - Preparation Method

Open Data Verified Data

The fruits, bark and leaves of Myrica rubra were extracted with water, ethanol or methanol and refined.

Last Update：2022-01-01 11:13:50

17912-87-7 - Use

Open Data Verified Data

can be used as an antioxidant. Added to cosmetics, has the effect of whitening the skin.

Last Update：2022-01-01 11:13:50

17912-87-7 - Reference Information

FEMA	4491 | MYRICITRIN
Biological activity	Myricitrin (Myricitrine) is a chemical compound that can be isolated from the root bark of Myrica cerifera (Bayberry genus, small tree, native to North America).
Target	Value
use	used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has the effects of constricting blood vessels, raising blood pressure, exciting the heart, choleretic, anti-inflammatory, mutagenic, etc. product name myricin; myricin; pentahydroxyflavone-3-rhamnoside

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Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

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We deliver goods within 3 days for small order, 7-10 days for bulk order.

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First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.