69884-00-0 (3b,6a,12b,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside

Details:

69884-00-0 - Names and Identifiers

Name	Pseudoginsenoside F11
Synonyms	GINSENOSIDE A1 Pseudoginsenoside F11 PSEUDOGINSENOSIDE F11 (24R)-Pseudoginsenoside F11 (20S,24R)-6α-(2-O-α-L-Rhamnopyranosyl-β-D-glucopyranosyloxy)-20,24-epoxy-5α-dammarane-3β,12β,25-triol [(24R)-20,24-Epoxy-3β,12β,25-trihydroxy-5α-dammaran-6α-yl]2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside (3beta,5xi,6alpha,9xi,12beta,24R)-3,12,25-trihydroxy-20,24-epoxydammaran-6-yl 2-O-(6-deoxyhexopyranosyl)hexopyranoside (3b,6a,12b,24R)-20,24-Epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside (3beta,6alpha,12beta,24R)-3,12,25-trihydroxy-20,24-epoxydammaran-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 17β-[[(2S)-2β-Methyl-5α-(1-hydroxy-1-methylethyl)tetrahydrofuran]-2-yl]-3β,12β-dihydroxy-4,4,8β,10β,14α-pentamethyl-5α-gonane-6α-yl 2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (6alpha,8xi,9xi,12alpha,13xi,14beta,17beta)-3,12-dihydroxy-17-[(2S,5R)-5-(1-hydroxy-1-methylethyl)-2-methyltetrahydrofuran-2-yl]-2,4,4,10,14-pentamethylgonan-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
CAS	69884-00-0
InChI	InChI=1/C42H72O14/c1-18-16-41(8)21-14-23(44)27-20(42(9)13-11-26(56-42)39(5,6)51)10-12-40(27,7)22(21)15-24(34(41)38(3,4)35(18)50)53-37-33(31(48)29(46)25(17-43)54-37)55-36-32(49)30(47)28(45)19(2)52-36/h18-37,43-51H,10-17H2,1-9H3/t18 ,19-,20-,21 ,22 ,23-,24-,25+,26+,27 ,28-,29+,30+,31-,32+,33+,34 ,35 ,36-,37+,40+,41+,42-/m0/s1

69884-00-0 - Physico-chemical Properties

Molecular Formula	C42H72O14
Molar Mass	801.01
Density	1.33±0.1 g/cm3(Predicted)
Melting Point	>196°C (dec.)
Boling Point	885.3±65.0 °C(Predicted)
Flash Point	491.8°C
Solubility	Soluble in solvents such as ethanol and methanol, insoluble in petroleum ether and chloroform.
Vapor Presure	0mmHg at 25°C
Appearance	White crystalline powder
Color	White
pKa	12.85±0.70(Predicted)
Storage Condition	2-8°C
Sensitive	Sensitive to air and light
Refractive Index	1.597
MDL	MFCD00803938
Physical and Chemical Properties	Soluble in solvents such as ethanol and methanol, insoluble in petroleum ether and chloroform. Panax ginseng ginseng C. A. Mey. Dry root

69884-00-0 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Safety Description	24/25 - Avoid contact with skin and eyes.
WGK Germany	3
HS Code	29389090

69884-00-0 - Reference

Reference  Show more

1. Gao Songhong, Yang Di, Li Zhongqi, Zheng Fei, JEON You-Jin, Dai Yulin. Analysis of pharmacokinetics of sijunzi decoct...

69884-00-0 - Reference Information

overview	[1-2] ginsenoside F11(PF11) is a octillol-type saponin, which only exists in American ginseng and is a landmark component that distinguishes American ginseng from ginseng. Its structure is (20S,24R)-6-O-[α-L-rhamopyranosyl-(1-2)-β-D-glucopyranosyl]-damar-20, 24-epoxy-3β, 6 α,12 β, 25-tetraol. Its main pharmacological activity is positive inotropic effect on isolated cardiac function, good therapeutic effect on myocardial ischemia, good protective effect on cardiovascular and cerebrovascular system and nervous system, and can improve intelligence and prevent dementia. Although PF11 has good biological activity, it is difficult to realize industrialization because it is less in nature. At present, there is not much research on PF11 at home and abroad, and its synthesis process is not mature. photo: American ginseng
source	[3] pseudoginseng soap was first discovered in American ginseng. it is a characteristic component of American ginseng that is different from ginseng. it belongs to oktiron soap camp and is a kind of ginseng soap camp. American ginseng Yin Dingding five belongs to the Wujia family. Ginseng is a herb. It was first found near the northern temperate zone of North America. The theory of traditional Chinese medicine believes that "American ginseng tastes sweet and slightly bitter, has a cool nature, and returns to the heart, lungs, and spleen meridian. Taking its root as medicine, it has the effects of invigorating qi and nourishing yin, clearing heat and promoting fluid production. It can be used for qi deficiency and yin deficiency, deficiency and heat tiredness, cough, asthma, phlegm and blood, internal heat and thirst, dry mouth and dry throat "'. American ginseng has been favored by people for its magical and unique pharmacological effects. With the successful introduction of American ginseng in China and Japan, the large-scale introduction and cultivation of American ginseng has become a reality. At present, four major ecological climate cultivation areas of American ginseng have been formed. Mainly distributed in Jilin Province, the planting area accounts for more than the country. The main active ingredient of American ginseng is ginseng soap, and it also contains polysaccharides, amino acids, polyacetylene and other ingredients. The first ginseng soap compound was isolated from the root of American ginseng as early as in, and it has been more than 100 years. In recent years, with the development of experimental technology and the successful introduction of American ginseng in China, the research on American ginseng has reached a new climax. At present, nearly a remaining soap compound has been isolated from American ginseng.
pharmacological activity	effect on cardiovascular and cerebrovascular system: ginseng soap camp has pharmacological activity to protect cardiovascular and cerebrovascular system. studies have shown that different doses of ginseng soap camp can reduce the area of cerebral infarction in cerebral ischemia rats, relieve their behavioral symptoms and reduce the degree of cerebral edema. Reduce the content of malondialdehyde in serum and reduce its pathological damage. In addition, studies have shown that ginseng soap can stimulate myocardial tissue to produce a large number of and one, thereby producing a protective effect on ischemic myocardium, by increasing the expression of the two to stimulate the regeneration of blood vessels in the myocardial infarction area and the establishment of collateral circulation. Effect on the nervous system: Ginseng soap camp has certain neuroprotective activity. Ginseng soap camp has the ability to enhance the antioxidant capacity of neurons and weaken the damage of oxygen free radicals to neurons. Anti-aging and anti-fatigue effects: Ginseng soap has significant anti-aging pharmacological activities. Its function is mainly manifested in anti-oxidation, scavenging free radicals, delaying the expression of aging genes, etc. The effect of ginseng soap camp on skin aging, it is found that ginseng soap camp can accelerate cell metabolism, increase skin activity, fully demonstrate the antioxidant effect of ginseng soap camp, and delay skin aging. Anti-tumor effect: Ginseng soap can inhibit the expression of growth factors in tumor cells and show anti-angiogenesis effect. Studies have shown that ginseng soap camp can well inhibit the canceration of cells and has the effect of chemical protection. A new kind of ginseng saponin was found in the degradation products of ginseng total saponin, and its anti-tumor cell activity was studied. It was found to have a significant inhibitory effect on proliferation.
references	[1] Li Wei. Study on structural modification and biological activity of ginsenoside [D]. Jilin University, 2010. [2] Wang Jinhui, li Xian. Study on Drug Metabolism of Ginsenoside F_(11) in Rats [J]. Journal of Pharmacy, 2001, 36(06):427-431. [3] Liu Haiyan. Study on Synthesis Technology of Ginsenoside F_(11) and Related Substances [D]. Jilin University, 2015.
Chemical properties	Soluble in solvents such as ethanol and methanol, insoluble in petroleum ether and chloroform. Panax ginseng ginseng C. A. Mey. Dried root
use	pharmacological effect: it has a strong and stable effect on improving learning and memory disorders in animals. Ginsenoside F11 is one of the main components of American ginseng, which can resist the loss of learning and memory ability induced by scopolamine, morphine and methamphetamine in mice.

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