P-BROMOBENZONITRILE

P-BROMOBENZONITRILE
P-BROMOBENZONITRILE
P-BROMOBENZONITRILE
P-BROMOBENZONITRILE

P-BROMOBENZONITRILE

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99.9% by HPLC
  • Payment Terms : L/C,T/T,Other

Keywords

4-Bromobenzonitrile Rilapladib iptacopan

Quick Details

  • Appearance:White crystallization
  • Application:Butyldimethylsilyloxyethylcarboxyet
  • PackAge:25kg/drum
  • ProductionCapacity:10|Metric Ton|Day
  • Storage:
  • Transportation:AIR SEA TRAIN

Superiority:

Product Name: 4-Bromobenzonitrile
Synonyms: PBBN;P-BROMOBENZONITRILE;4-BROMOBENZONITRILE FOR SYNTHESIS;4-Cyanophenyl bromide;p-Cyanobromobenzene;p-Cyanophenyl bromide;A nitrile of broMobenzene;Of broMoxynil
CAS: 623-00-7
MF: C7H4BrN
MW: 182.02
EINECS: 210-764-9
Product Categories: Building Blocks;C6 to C7;Phenyls & Phenyl-Het;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Nitrile;Nitriles;Miscellaneous;Bromine Compounds;Benzonitriles (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Phenyls & Phenyl-Het;FINE Chemical & INTERMEDIATES;blocks;Bromides;Carboxes;Halides;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds;bc0001
Mol File: 623-00-7.mol
4-Bromobenzonitrile Structure
 
4-Bromobenzonitrile Chemical Properties
Melting point  110-115 °C(lit.)
Boiling point  235-237 °C(lit.)
density  1,562 g/cm3
refractive index  1.5999 (estimate)
Fp  130°C
storage temp.  Sealed in dry,Room Temperature
solubility  0.2g/l
form  Powder or Flakes
color  White to light yellow or flakes
Water Solubility  Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.
BRN  2041518
InChIKey HQSCPPCMBMFJJN-UHFFFAOYSA-N
LogP 2.3 at 22.5℃ and pH7
CAS DataBase Reference 623-00-7(CAS DataBase Reference)
NIST Chemistry Reference 4-Bromobenzoic acid nitrile(623-00-7)
 
Safety Information
Hazard Codes  Xn,T,Xi
Risk Statements  22-36/37/38-20/21/22
Safety Statements  61-36/37/39-26-24/25
RIDADR  UN 3439 6.1/PG 3
WGK Germany  2
RTECS  DI2460000
Hazard Note  Toxic/Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29269095

Details:

4-Bromobenzonitrile Usage And Synthesis
Chemical Properties 4-Bromobenzonitrile is white to light yellow powder or flakes
Uses 4- Bromobenzonitrile is classified as organic nitriles, which are commonly use solvents and are reacted further for various applications such as manufacture of polymers and intermediates for pharmaceu ticals and other organic chemicals,
Uses 4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.
Synthesis Reference(s) Tetrahedron Letters, 27, p. 1925, 1986 DOI: 10.1016/S0040-4039(00)84413-5
Synthesis To a 10 mL glass tube aryl halide (1 mmol), K4FeCN6 (0.6 mmol,220 mg), K2CO3 (1.5 mmol, 207 mg), catalyst (10 mg), and 2 mL DMF were added and the mixture was stirred for appropriate reaction time at 120 ℃ under argon atmosphere. The progress of the reaction was monitored by GC analysis. After completion of the reaction, the reaction mixture was washed with 5 mL water, and the crude product was isolated using dichloromethane (5× 1 mL). Organic extracts were combined, evaporated, and purified by flash chromatography using hexane/EtOAc to give 4-Bromobenzonitrile.
4-Bromobenzonitrile
 
4-Bromobenzonitrile Preparation Products And Raw materials
Preparation Products 4-CYANOSTYRENE-->1-Boc-4-(4-methoxycarbonylphenyl)piperazine-->4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid-->4-Bromobenzamidine hydrochloride-->2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER-->4-Cyanophenylboronic acid-->4-Bromo-2-chlorobenzonitrile-->4-N-BUTOXYBENZONITRILE-->4-Guanidinobenzoic acid hydrochloride-->4-CYANOBENZOPHENONE-->3-(4-CYANO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER-->2,4'-DIBROMOPROPIOPHENONE-->(4-CYANOBENZYL)PHOSPHONIC ACID DIETHYL ESTER-->TERT-BUTYL 4-CYANOPHENYLCARBAMATE-->4-(Pentafluoroethyl)benzonitrile

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