Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Exam

Authoritative Data Verified Data

alkalinity

take this product O.lg, add water 10ml to dissolve, according to the law to determine (General 0631),pH value should be 8.0~9.5.

clarity and color of solution

take this product O.lg, after dissolving by adding 10ml of water, the solution shall be clear and colorless; In case of color development, it shall not be deeper in comparison with yellow or orange-yellow No. 2 Standard Colorimetric solution (General rule 0901 first method).

Related substances

take this product, precision weighing, add acetonitrile-water (9:1) to dissolve and dilute to make a solution containing about 5mg per 1 ml, as a test solution; take 1 ml of precision, 100ml flask, diluted with acetonitrile-water (9:1) to the scale, shake, as a control solution. According to the chromatographic conditions under the content determination item, l0ul of the control solution and the test solution are accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 2.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the known impurities shall be calculated by the principal component self-control method with correction factor (see table below), other unknown impurities shall be calculated by the main component self-control method without correction factor, and impurity I shall not exceed 0.2%, impurities II and III shall not exceed 0.1%, and impurities IV and V shall not exceed 0.3%, other individual impurities shall not exceed 0.2%, and the total amount of impurities shall not exceed 1.5%. The chromatographic peak before impurity I was not counted.

residual solvent

take about 20% g of this product, precision weighing, top empty bottle, precision plus N,N-dimethylformamide solution 5M l dissolved, sealed, as a test solution; Another methanol, ethanol, diethyl ether, acetone, isopropanol, acetonitrile and two gas methane each appropriate amount, precision weighing, with 20% N,N-dimethylformamide solution quantitative dilution made of methanol in about 300ug per 1 ml, ethanol 500ug, diethyl ether 500uh, acetone 500ug, isopropyl alcohol 500ug, acetonitrile 41ug and dichloromethane 60ug mixed solution, precision volume 5ml, in the top empty bottle, sealed, as a reference solution. According to the determination method of residual solvent (General Principle 0861 second method), the capillary column with 6% cyanopropylphenyl-94% dimethyl polysiloxane (or similar polarity) as stationary liquid is used as the column; The initial column temperature is 45°C, hold for 10 minutes, then raise the temperature to 180°C at a rate of 20°C per minute for 2 minutes; The inlet temperature is 200°C; The detector temperature is 250°C; The equilibrium temperature of the headspace bottle is 90°C, the equilibration time was 30 minutes. Take the reference solution into the headspace, the separation degree between the peaks of each component shall meet the requirements. Take the reference solution and the test solution into the headspace respectively, record the chromatogram, calculate the peak area according to the external standard method, methanol, ethanol, ether, acetone, isopropanol, the residual amounts of acetonitrile and dichloromethane shall be in accordance with the regulations.

moisture

take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 4.0%.

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

identification

1. in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
2. take 5ml of this product and dilute it to 15ml with water for identification reaction of bromide (General rule 0301).

examination

• the pH value should be 3.8 to 4.2 (General 0631).
• clarity and color of the solution this product should be clear and colorless; If the color is colored, it should not be deeper compared with the yellow or orange 2 Standard Colorimetric solution (General Principles 0901 first method).
• an appropriate amount of the related substances (about 5mg of rocuronium bromide) was accurately weighed, placed in a suitable container, and dried at 45 ° C. Or lower with nitrogen gas. Precision Add acetonitrile 2ml, Vortex, ultrasonic, centrifugal, take the supernatant as the test solution; Precision take 1ml, put 100ml flask, with acetonitrile-water (9:1) dilute to the scale, as a control solution; Take the blank solvent (take sodium chloride 30mg, sodium acetate 20mg, sodium bromide 17mg, add water 10ml to dissolve, adjust the pH value to 4.0 with glacial acetic acid) 1ml, according to the same method as the test solution, the solution obtained is used as blank solution; According to the method under the item of rocuronium bromide related substances, if there are impurity peaks in the chromatogram of the test solution, known impurities are calculated by the principal component self-control method with correction factor, and other unknown impurities are calculated by the principal component self-control method without correction factor, impurity I shall not exceed 0.2%, impurity II, III shall not exceed 0.1%, impurity IV shall not exceed 0.3%, impurity V shall not exceed 2.0%, other individual impurities shall not exceed 0.2%, and the total amount of impurities other than impurity V shall not exceed 0.6%. The chromatographic peaks before the blank solution and impurity I were not counted.
• bacterial endotoxin this product, according to the law to check (General 1143), each 1 mg rocuronium bromide containing endotoxin amount should be less than 2.2EU.
• others should comply with the relevant provisions under injection (General 0102).

Content determination

• measured by high performance liquid chromatography (General 0512).
• chromatographic conditions and system suitability test with silica gel as filler; 0.O25mol/L tetramethyl ammonium hydroxide solution (take 25% tetramethyl ammonium hydroxide aqueous solution 9.1ml or take 4.53g tetramethyl ammonium hydroxide pentahydrate, add water 900ml, shake, adjust pH to 7.4 with phosphoric acid and dilute to ML with water-acetonitrile (10:90) as mobile phase; Flow rate 2.0mL per minute; Detection wavelength 210nm. Take the appropriate amount of rocuronium impurity I, II, III, IV, V and rocuronium reference respectively, and add acetonitrile-water (9:1). Dissolve (when impurity IV is dissolved, dilute hydrochloric acid can be added 1 drop to help solubilize) and dilute to prepare 1 mg of rocuronium bromide and 0 each of impurities I, II, III, IV and V per 1 ml. A mixed solution of 1 mg is used as a system-applicable solution. Inject into the liquid chromatograph, the peak order is bromide ion peak, impurity I, II, III, IV, rocuronium bromide and impurity V; the number of theoretical plates shall not be less than 5000 according to the calculation of the rocuronium peak, and the separation degree between the rocuronium peak and the impurity V peak shall be greater than 3.5.
• determination of precision take 5ml of this product, put it in a 50ml measuring flask, dilute to the scale with acetonitrile, shake, as a test solution, take 10 u1, note human liquid chromatograph, record chromatogram; Take appropriate amount of rocuronium bromide reference substance, precisely weigh, dilute with acetonitrile-water (9:1) to about 1 mg solution per 1 ml, as a control solution, the same method. According to the external standard method to calculate the peak area, that is.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.