17455-13-9 18-Crown-6 with Fast Delivery and Enough Stock.

Details:

58-55-9 - Names and Identifiers

Name	Theophylline
Synonyms	accurbron Theophylline Acet-theocin dimethylxanthine 1,3-dimethyl-xanthin Theophylline anhydrous 3h)-dione,1,3-dimethyl-purine-6(1h 3,7-dihydro-1,3-dimethyl-1h-purine-6-dione 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione 6-dione,3,7-dihydro-1,3-dimethyl-1H-Purine-2 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl- 1,3-dimethyl-3,4,5,7-tetrahydro-1H-purine-2,6-dione
CAS	58-55-9
EINECS	200-385-7
InChI	InChI=1/C7H10N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3-5H,1-2H3,(H,8,9)
InChIKey	ZFXYFBGIUFBOJW-UHFFFAOYSA-N

58-55-9 - Physico-chemical Properties

Molecular Formula	C7H8N4O2
Molar Mass	180.16
Density	1.3640 (rough estimate)
Melting Point	271-273°C
Boling Point	312.97°C (rough estimate)
Flash Point	11°C
Water Solubility	8.3 g/L (20 ºC)
Solubility	Soluble in water, ethanol, chloroform, soluble in alkali, ammonia and dilute acid, insoluble in ether.
Vapor Presure	2.72E-06mmHg at 25°C
Appearance	White to off-white crystalline powder
Color	white
Merck	14,9285
BRN	13463
pKa	8.77(at 25℃)
Storage Condition	2-8°C
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Sensitive to air
Refractive Index	1.6700 (estimate)
MDL	MFCD00079619
Physical and Chemical Properties	White Crystal or crystalline powder, odorless, bitter taste. Mp270-274. It is soluble in water (1:120), ethanol (1:18), chloroform (1:86), alkali hydroxide, ammonia, dilute hydrochloric acid and dilute nitric acid at room temperature, slightly soluble in ether. Moderate toxicity, LD50 (rat, oral) 300mg/kg.
Use	Mainly used for the treatment of bronchial and cardiac asthma, can also be used for cardiac edema

58-55-9 - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S24/25 - Avoid contact with skin and eyes.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	1
RTECS	XH3850000
FLUKA BRAND F CODES	10-23
TSCA	Yes
HS Code	29395900
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 oral in rabbit: 350mg/kg

58-55-9 - Reference

Reference  Show more

1. Dong Yanru, Cao Yanyan, Lu Jiachun, Mei Sifan, he run, Chen Ping. Crystallographic study of catechin-caffeine complex...

58-55-9 - Standard

Authoritative Data Verified Data

This product is 1, 3-dimethyl-3, 7-dihydro-1h-purine-2, 6-dione monohydrate or anhydrous. Calculated as dry, containing no less than 99.0% anhydrous theophylline (C7H8N4O2).

 

58-55-9 - Trait

Authoritative Data Verified Data

• This product is white crystalline powder; Odorless.
• This product is slightly soluble in ethanol or chloroform, very slightly soluble in water, almost insoluble in ether; Soluble in potassium hydroxide solution or ammonia solution.

 

58-55-9 - Differential diagnosis

Authoritative Data Verified Data

1. take about 10 mg of this product, add 1 ml of hydrochloric acid and 0.lg of potassium chlorate, and steam dry on a water bath, leaving light red residue, which will turn purple when ammonia is encountered. Add several drops of sodium hydroxide test solution, and the purple color will disappear.
2. take about 50mg of this product, add 1 ml of sodium hydroxide solution to dissolve, add 3ml of nitrogen benzene sulfonic acid solution, should be red.
3. take about 10mg of this product, add 5ml of water to dissolve, add 3ml of ammonia-ammonium chloride buffer (pH 8.0), and then add 1 ml of copper pyridine test solution. After shaking, add 5ml of chloroform and shake, the chloroform layer was green.
4. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 272).

 

58-55-9 - Exam

Authoritative Data Verified Data

acidity

take 0.10g of this product, dissolve 25ml of heated water, add 1 drop of Methyl red indicator solution and 0.02 ml of sodium hydroxide titration solution (0.20 mol/L), which should be yellow.

Related substances

take this product, add mobile phase to dissolve and dilute to make a solution containing 2mg per 1 ml as a test solution; Take appropriate amount of precision, A solution containing 10ug per lml was prepared by quantitative dilution with mobile phase as a control solution. An appropriate amount of theophylline and theobromine was separately taken, and the mobile phase was added to dissolve and dilute to prepare a solution containing 10ug per lml, as a system suitability solution. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Acetate buffer solution (1.36g of sodium acetate was taken, of water was added to dissolve, and 5ml of glacial acetic acid was added, then diluted to 1000ml with water, and the mobile phase was acetonitrile (93:7). The detection wavelength was 271nm. The applicable solution 20 u1 of the system is injected into the liquid chromatograph, and the chromatogram is recorded. The number of theoretical plates is not less than 5000 calculated by theophylline peak, and the separation degree between theobromine peak and theophylline peak should be greater than 2.0. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.2 times (0.1%) of the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 9.5%; For anhydrous theophylline, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

not more than 0.1% (General rule 0841).

 

58-55-9 - Content determination

Authoritative Data Verified Data

take this product about 0.3g, precision weighing, add water 50ml, slightly dissolve, cool, add silver nitrate titration solution (0.lmol/L)25ml, plus bromothymol blue indicator solution 1ml, shake, with sodium hydroxide titration solution (0.1 mol/L) titration to a blue color of the solution. Each 1ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 18.02mg of C7H8N402.

 

58-55-9 - Category

Authoritative Data Verified Data

smooth muscle relaxant.

 

58-55-9 - Storage

Authoritative Data Verified Data

sealed storage.

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

Superiority
As a reliable partner for Chinese market, we are specialized in chemical raw materials; consolidate sourcing, marketing, sales, distribution and after-sale services, providing our partners with sourcing evaluation, technology supports, toll/contract manufacture, investment solution and suitable partnership establishment in China.
Service we can provide:
1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment
5.Mix and different products in ONE PCL,increase the working efficiency for customers.
6.We can export from many China main ports,convenient for the customes provide logistics services.
Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

FAQ: 
1.Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3.How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5.Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6.How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

9.How do you treat quality complaint

First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.