Tomatidine hydrochloride 6192-62-7

Min.Order / FOB Price:Get Latest Price

5 Kilogram	FOB Price:USD 45.0000 -65.0000

5 Kilogram

FOB Price:USD 45.0000 -65.0000

Min.Order :5 Kilogram
Purity: >99%
Payment Terms : L/C,D/A,D/P,T/T

Keywords

(3beta,5alpha,22beta,25S)-Spirosolan-3-ol hydrochloride TOMATIDINE HCL SPIRPSOLAN-3-OL-(3B,5A,22B,25C) HCL

Quick Details

Appearance:White Crystalline Powder
Application:Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). Cytosine reagent is used in a wide variety of research applications, as an
PackAge:Brown vial or HDPE plastic bottle
ProductionCapacity:3000|Kilogram|Month
Storage:Cool Dry Place
Transportation:Bag or Drum

Superiority:

OEM Supply Superior Quality 99% Cytosine CAS 71-30-7

Basic Information:

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

Cytosine reagent is used in a wide variety of research applications, as an enzyme-substrate or precursor of effector molecules such as cytosine sugars.

Product Name:	Cytosine
Synonyms:	4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE
CAS:	71-30-7
MF:	C4H5N3O
MW:	111.1

Details:

Molecular Formula	C27H46ClNO2
Molar Mass	452.11
Melting Point	281-284°C (dec.)
Solubility	Methanol (Slightly)
Appearance	Powder
Color	White to Off-White
BRN	3920740
Storage Condition	2-8°C
In vitro study	Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.