(-)PPP 477-47-4

Min.Order / FOB Price:Get Latest Price

5 Kilogram	FOB Price:USD 45.0000 -65.0000

5 Kilogram

FOB Price:USD 45.0000 -65.0000

Min.Order :5 Kilogram
Purity: >99%
Payment Terms : L/C,D/A,D/P,T/T

Keywords

Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, [5R-(5a,5aa,8aa,9a)]- PICROPODOPHYLLIN Picropodophyllin(6CI,7CI,8CI)

Quick Details

Appearance:White powder
Application:Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). Cytosine reagent is used in a wide variety of research applications, as an
PackAge:Brown vial or HDPE plastic bottle
ProductionCapacity:3000|Kilogram|Month
Storage:Cool Dry Place
Transportation:Bag or Drum

Superiority:

OEM Supply Superior Quality 99% Cytosine CAS 71-30-7

Basic Information:

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

Cytosine reagent is used in a wide variety of research applications, as an enzyme-substrate or precursor of effector molecules such as cytosine sugars.

Product Name:	Cytosine
Synonyms:	4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE
CAS:	71-30-7
MF:	C4H5N3O
MW:	111.1

Details:

Molecular Formula	C22H22O8
Molar Mass	414.41
Density	1.370
Melting Point	225-227℃
Boling Point	453.31°C (rough estimate)
Specific Rotation(α)	D20 +9.4° (c = 0.7 in chloroform)
Solubility	Soluble in DMSO, insoluble in water
Appearance	Powder
Color	white
pKa	13.26±0.40(Predicted)
Storage Condition	Sealed in dry,2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Sensitive	Light Sensitive
Refractive Index	1.4480 (estimate)
MDL	MFCD01742647
Physical and Chemical Properties	White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from the rhizome of Berberis plant octagonal lotus Dysosma versipellis(Hance.)M.Cheng, peach seven.
In vitro study	In intact cells, PPP potently inhibited IGF-1 of Akt (Ser 473) and Erk1/2 phosphorylation stimulated by IGF-1R. In IGF-1R positive tumor cells in culture, picropodophylin specifically inhibited cell growth and induced apoptosis. Picropodopylin synergistically sensitized HMCL, primary human MM and mouse 5T33MM cells to ABT-737 and ABT-199 by further reducing cell viability and enhancing apoptosis. Picropodopylin and sorafenib synergistically inhibit the proliferation and activity of hepatocellular carcinoma.
In vivo study	In SCID mice xenografted with human ES-1,BE, and PC3, Picropodophyllin (20 mg/kg/12 h, I. p.) caused complete tumor regression. In the 5t33mm mouse model, Picropodophyllin also showed potent anti-tumor activity and significantly increased survival.