Fmoc-Glu(OtBu)-Gly-OH

Details:

Common name: Fmoc-Glu(OtBu)-Gly-OH

Category:FMOC amino acid

Other name: Fmoc-Glu(OtBu)-Gly

CAS No.: 866044-63-5

EINECS No.: /

Appearance: Powder

Molecular formula: C26H30N2O7

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	482.53
Boiling point	748.2±60.0 °C(Predicted)
Melting point	/
Density	1?+-.0.06 g/cm3(Predicted)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	3.34±0.10(Predicted)
Soluble	/
Water solubility	/
Color	White

 

 

Product Description:
Fmoc - Glu(OtBu) - Gly - OH is a white to off - white crystalline powder. Structurally, it consists of a glycine unit linked to a glutamic acid derivative. The amino - terminal of the peptide fragment is protected by the 9 - fluorenylmethyloxycarbonyl (Fmoc) group, which is stable under normal conditions but can be selectively removed under mild basic conditions. The carboxyl group of the glutamic acid residue is esterified with a tert - butyl group (OtBu), which not only protects the side - chain carboxyl but also affects the compound's solubility and reactivity. The glycine unit at the other end provides an additional site for further peptide bond formation. This compound has low solubility in water but dissolves well in common organic solvents like N,N - dimethylformamide (DMF) and dichloromethane.

In the field of peptide synthesis, Fmoc - Glu(OtBu) - Gly - OH serves as a crucial intermediate. It is widely used in the step - by - step assembly of complex peptides. By participating in coupling reactions with other amino acid derivatives, it enables the construction of long - chain peptides with specific sequences. The presence of the protected glutamic acid side - chain and the Fmoc - protected amino - terminal allows for precise control over the peptide - building process. Additionally, in pharmaceutical research, it contributes to the synthesis of bioactive peptides that may have potential therapeutic applications. To maintain its quality and reactivity, it should be stored in a cool, dry environment, away from light and heat.

 

Application: 

Fmoc - Glu(OtBu) - Gly - OH is primarily used in peptide synthesis. It serves as a key intermediate for constructing complex peptides with specific sequences. By coupling with other amino acid derivatives, it enables step - by - step peptide assembly. In pharmaceutical research, it contributes to the synthesis of bioactive peptides for potential therapeutic uses.

Package: 25kg/drum or bag

Storage: Keep in dark place, Sealed in dry, Room Temperature

Executive Standards: International Standard.