1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-

Details:

Common name: 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-

Category:PROTAC functional molecule

Other name: 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47

CAS No.: 1256094-31-1

EINECS No.: /

Appearance: Solid

Molecular formula: C13H8F3N3O

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	279.22
Boiling point	411.7±55.0 °C(Predicted)
Melting point	/
Density	1.439±0.06 g/cm3(Predicted)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	8.87±0.10(Predicted)
Soluble	/
Water solubility	/
Color	White

 

 

Product Description:
1H - Benzimidazole, 2 - (2 - pyridinyl)-6 - (trifluoromethoxy)- usually exists as a crystalline solid, often with a white to light - beige color. Structurally, it features a benzimidazole core, which is a fused - ring structure composed of a benzene ring and an imidazole ring. At the 2 - position of the benzimidazole ring, a 2 - pyridinyl group is attached, introducing a nitrogen - containing heterocyclic moiety. Meanwhile, at the 6 - position, a trifluoromethoxy group is present. The trifluoromethoxy group, with its three fluorine atoms and an oxygen atom bonded to a methyl - like carbon, imparts strong electron - withdrawing and hydrophobic properties to the molecule. The 2 - pyridinyl group not only contributes to the basicity of the compound due to its nitrogen atom but also provides additional sites for chemical reactions and interactions.

In terms of solubility, this compound has poor solubility in water because of the combined hydrophobic nature of the trifluoromethoxy group and the aromatic rings. However, it shows good solubility in common organic solvents such as dichloromethane, chloroform, and N,N - dimethylformamide (DMF). In chemical reactions, the nitrogen atoms in the imidazole and pyridine rings can act as nucleophiles, participating in reactions like alkylation and acylation. The benzimidazole ring system itself is also reactive under certain conditions, for example, it can undergo substitution reactions on the benzene part of the ring.

In the fields of pharmaceutical and material science research, 1H - Benzimidazole, 2 - (2 - pyridinyl)-6 - (trifluoromethoxy)- plays an important role. In pharmaceuticals, it can serve as a key intermediate for the synthesis of drugs with potential biological activities, such as acting as inhibitors for specific enzymes or receptors. In material science, derivatives of this compound may be used in the preparation of functional materials with unique optical or electronic properties. To maintain its quality and reactivity, it should be stored in a cool, dry environment, away from strong oxidants, light, and heat sources.

 

Application: 

1H - Benzimidazole, 2 - (2 - pyridinyl)-6 - (trifluoromethoxy)- is used as a key intermediate in pharmaceutical synthesis for drugs with potential biological activities like enzyme or receptor inhibitors. In material science, its derivatives help prepare functional materials with unique optical or electronic properties.

Package: 25kg/drum or bag

Storage: Sealed in dry, room temperature.

Executive Standards: International Standard.