Cyclohexaneacetic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]- (9CI)

Details:

Common name: Cyclohexaneacetic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]- (9CI)

Category:PROTAC linker

Other name: 4-(Boc-amino)cyclohexaneacetic acid

CAS No.: 344933-31-9

EINECS No.: /

Appearance: Powder

Molecular formula: C13H23NO4

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	257.33
Boiling point	414.9±14.0 °C(Predicted)
Melting point	/
Density	1.11±0.1 g/cm3(Predicted)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	4.72±0.10(Predicted)
Soluble	/
Water solubility	/
Color	White

 

 

Product Description:
Cyclohexaneacetic acid, 4 - [[(1,1 - dimethylethoxy)carbonyl]amino]- (9CI) generally presents as a white to off - white crystalline solid. Structurally, it contains a cyclohexane ring, with an acetic acid moiety attached to it. At the 4 - position of the cyclohexane ring, an amino group is protected by a tert - butoxycarbonyl (BOC) group, which is the (1,1 - dimethylethoxy)carbonyl group. The cyclohexane ring provides a relatively rigid and non - polar framework, while the acetic acid group at the end imparts some degree of acidity and reactivity. The BOC - protected amino group is stable under normal conditions but can be selectively removed under mild acidic conditions, which is crucial for further chemical modifications.

In terms of solubility, it has low solubility in water due to the hydrophobic nature of the cyclohexane ring and the BOC group. However, it is soluble in many common organic solvents such as dichloromethane, ethyl acetate, and N,N - dimethylformamide (DMF). In chemical reactions, the carboxylic acid group of the acetic acid part can participate in esterification reactions with alcohols, and the BOC - protected amino group can be deprotected and then react with other electrophiles. The cyclohexane ring can also undergo substitution reactions under certain conditions.

In the fields of organic synthesis and pharmaceutical research, this compound plays a significant role. In organic synthesis, it serves as an important building block for constructing more complex molecules. For example, the BOC - protected amino group and the carboxylic acid group can be used in peptide - like synthesis to form amide bonds with other amino - acid derivatives or amine - containing compounds. In pharmaceutical research, it can be used as a starting material for the synthesis of potential drug candidates. Modifying the structure around the cyclohexane ring and the functional groups can lead to the development of molecules with specific biological activities. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from light, heat, and moisture.

 

Application: 

Cyclohexaneacetic acid, 4 - [[(1,1 - dimethylethoxy)carbonyl]amino]- (9CI) is used as a building block in organic synthesis for constructing complex molecules, especially in peptide - like synthesis. In pharmaceutical research, it serves as a starting material for potential drug candidates by modifying its structure to obtain specific biological activities.

Package: 25kg/drum or bag

Storage: Sealed in dry, room temperature

Executive Standards: International Standard.