(4-METHOXY-BENZOYLAMINO)-ACETIC ACID

Details:

Common name: (4-METHOXY-BENZOYLAMINO)-ACETIC ACID

Category:PROTAC linker

Other name: 4-methyoxybenzoyl-N-glycine

CAS No.: 13214-64-7

EINECS No.: /

Appearance: Solid

Molecular formula: C10H11NO4

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	209.2
Boiling point	463.7±30.0 °C(Predicted)
Melting point	155-158°C
Density	1.268±0.06 g/cm3(Predicted)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	3.53±0.10(Predicted)
Soluble	/
Water solubility	/
Color	/

 

 

Product Description:
4 - (Methoxy - benzoylamino) - acetic acid typically presents as a white to off - white crystalline solid. Structurally, it consists of an acetic acid moiety, with an amino group acylated by a 4 - methoxy - benzoyl group. The 4 - methoxy - benzene ring in the benzoyl part provides a certain degree of hydrophobicity and electronic characteristics due to the presence of the methoxy group, which can influence the compound's reactivity. The carbonyl group in the benzoyl moiety is highly reactive, especially towards nucleophiles, and the methoxy group on the benzene ring can participate in various substitution and electrophilic aromatic substitution reactions under appropriate conditions. The acetic acid part, with its carboxyl group, endows the compound with acidic properties. This carboxyl group can react with bases to form salts, and can also participate in esterification reactions with alcohols or amide - forming reactions with amines in the presence of suitable coupling agents.

 

In terms of solubility, it has limited solubility in water because of the relatively non - polar benzene ring, but it shows better solubility in polar organic solvents such as ethanol, methanol, and N,N - dimethylformamide (DMF). In chemical reactions, the carbonyl group of the benzoyl moiety can be reduced to an alcohol under certain reducing conditions. The amino - carbonyl (amide) bond can be cleaved under acidic or basic hydrolysis conditions. The carboxyl group of the acetic acid part can be activated to form reactive intermediates for further chemical modifications.

 

In the fields of organic synthesis and pharmaceutical research, 4 - (Methoxy - benzoylamino) - acetic acid is of great significance. In organic synthesis, it serves as a useful building block for constructing more complex molecules. For example, the carboxyl group and the amide - linked structure can be utilized in sequence to create multi - functional compounds. In pharmaceutical research, it can be a starting material for the synthesis of drugs that target specific biological pathways. Modifying the substituents on the benzene ring or the functional groups attached to the acetic acid part can potentially lead to the discovery of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry environment, away from moisture, heat, and strong oxidizing agents.

 

Application: 

4 - (Methoxy - benzoylamino) - acetic acid is used in organic synthesis as a building block for complex molecule construction. In pharmaceutical research, it's a starting material for drug synthesis, helping to develop novel bioactive substances by modifying its structure.

Package: 25kg/drum or bag

Storage: Sealed in dry, room temperature

Executive Standards: International Standard.