Ataluren PTC 124 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
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Common name: Ataluren
Category:APIs
Other name: 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
CAS No.: 775304-57-9
EINECS No.: /
Appearance: Solid
Molecular formula: C15H9FN2O3
Brand Name: Colorcom
Shelf Life: 2 Years
Place of Origin: China
Product Specification:
Molecular Weight |
284.24 |
Boiling point |
503.7±60.0 °C(Predicted) |
Melting point |
241 - 242°C |
Density |
1.379 |
Purity |
≥99.0% |
PH |
/ |
Acidity coefficient (pKa) |
3.58±0.10(Predicted) |
Soluble |
Dimethyl sulfoxide |
Water solubility |
/ |
Color |
White |
Product Description:
Ataluren usually appears as a white to off - white crystalline solid. Structurally, it is a small - molecule compound with a unique chemical structure that contains specific functional groups crucial for its biological activity. These functional groups endow it with the ability to interact with ribosomes in a distinct way.
In terms of solubility, it has limited solubility in water, but shows better solubility in some organic solvents like ethanol and dimethyl sulfoxide (DMSO). Under normal storage conditions, it remains relatively stable chemically, yet it may undergo reactions under extreme acidic or basic conditions.
Pharmacologically, Ataluren is designed to address a particular genetic defect. It works by promoting read - through of premature stop codons during translation, allowing the ribosome to continue protein synthesis. This mechanism holds great promise for treating genetic disorders caused by nonsense mutations. Clinically, it is mainly investigated for the treatment of Duchenne muscular dystrophy (DMD) and other genetic diseases associated with nonsense mutations. By enabling the production of functional proteins, it has the potential to improve the symptoms and quality of life for patients suffering from these conditions. To maintain its quality and efficacy, Ataluren should be stored in a cool, dry environment, away from light, heat, and humidity.
Application:
Ataluren is mainly used to treat genetic diseases caused by nonsense mutations, like Duchenne muscular dystrophy. It promotes read - through of premature stop codons during translation, enabling functional protein production to improve patients' symptoms and quality of life.
Package: 25kg/drum or bag
Storage: Refrigerator.
Executive Standards: International Standard.
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