Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Details:

Common name: Dapagliflozin propanediol monohydrate

Category:APIs

Other name: /

CAS No.: 960404-48-2

EINECS No.: 811-335-4

Appearance: Solid

Molecular formula: C24H33ClO8

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	484.97
Boiling point	/
Melting point	74 - 78°C
Density	/
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	/
Soluble	Soluble in chloroform (a little), DMSO (a little), methanol (a little)
Water solubility	/
Color	White

 

 

Product Description:
Dapagliflozin propanediol monohydrate typically presents as a white to off - white powder. Structurally, it is a derivative of dapagliflozin, a well - known sodium - glucose co - transporter 2 (SGLT2) inhibitor. It combines the core structure of dapagliflozin with propanediol and a water molecule in a monohydrate form. The SGLT2 - inhibitory functional groups in the dapagliflozin part are crucial for its biological activity. The addition of propanediol and the water molecule in the monohydrate form can influence its physical properties such as solubility and stability.

In terms of solubility, it has improved solubility characteristics compared to dapagliflozin in some media due to the presence of propanediol and the hydrated state. It shows solubility in water and certain polar solvents. Under normal storage conditions, it remains relatively stable. However, it may be affected by extreme environmental conditions like high temperatures, high humidity, or exposure to strong acids or bases.

Pharmacologically, like dapagliflozin, it inhibits the SGLT2 in the kidneys. This inhibition blocks the reabsorption of glucose from the renal tubules back into the bloodstream, leading to increased urinary glucose excretion. As a result, it helps to lower blood glucose levels in a glucose - independent manner. Clinically, it is mainly used for the treatment of type 2 diabetes mellitus. It can be used alone or in combination with other antidiabetic medications to effectively control blood glucose levels in patients with type 2 diabetes. Additionally, it may also have beneficial effects on reducing cardiovascular risks and improving renal function in some patients. To maintain its quality and effectiveness, Dapagliflozin propanediol monohydrate should be stored in a cool, dry place, away from light, heat, and moisture.

 

Application: 

Daglizin monohydrate is an SGLT2 inhibitor that can be used to treat diabetes.

Package: 25kg/drum or bag

Storage: -20°C Freezer

Executive Standards: International Standard.