Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Details:

Common name: Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Category:Febuxostat intermediates

Other name: 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester

CAS No.: 161797-99-5

EINECS No.: 605-268-8

Appearance: Solid

Molecular formula: C13H13NO3S

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	263.31
Boiling point	426.8±55.0 °C(Predicted)
Melting point	180 °C
Density	1.274
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	8.56±0.15(Predicted)
Soluble	Soluble in DMSO (slight), methanol (very slight)
Water solubility	/
Color	Creamy white

 

 

Product Description:
Ethyl 2-(4 - hydroxyphenyl)-4 - methylthiazole - 5 - carboxylate commonly presents as a pale - yellow to light - brown crystalline solid. Structurally, it features a thiazole ring fused with a 4 - hydroxyphenyl group at the 2 - position and a methyl group at the 4 - position of the thiazole ring, along with an ethyl carboxylate moiety at the 5 - position. The 4 - hydroxyphenyl group imparts polarity and reactivity due to the hydroxyl group, which can engage in hydrogen - bonding interactions and substitution reactions such as esterification and etherification under appropriate conditions. The thiazole ring, with its sulfur and nitrogen heteroatoms, endows the compound with unique chemical and biological properties. The sulfur atom in the thiazole ring can act as a nucleophile in certain reactions, and the nitrogen atom can participate in acid - base interactions. The ethyl carboxylate group can be hydrolyzed under acidic or basic conditions to yield the corresponding carboxylic acid or can be used in ester - exchange reactions.

In terms of solubility, it has low solubility in water because of the relatively non - polar thiazole and phenyl rings. However, it exhibits good solubility in polar organic solvents like ethanol, acetone, and dichloromethane. In chemical reactions, the hydroxyl group can be easily modified, for example, by reacting with acyl chlorides to form esters. The thiazole ring can also undergo electrophilic substitution reactions at positions activated by the electron - donating groups attached to it.

In the fields of organic synthesis and pharmaceutical research, Ethyl 2-(4 - hydroxyphenyl)-4 - methylthiazole - 5 - carboxylate is of great importance. In organic synthesis, it serves as a valuable building block for constructing more complex molecules. By reacting the different functional groups present in the molecule with various reagents, a wide range of functionalized compounds can be synthesized. In pharmaceutical research, it may act as a potential intermediate for the synthesis of drugs with diverse biological activities. Modifying the substituents on the phenyl or thiazole rings can potentially lead to the discovery of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from light, heat, moisture, and strong oxidizing agents.

 

Application: 

Febuxostat intermediate.

Package: 25kg/drum or bag

Storage: Sealed in dry, Room Temperature

Executive Standards: International Standard.