(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Details:

Common name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Category:Empagliflozin intermediates

Other name: 2-Chloro-4'-fluoro-5-iodobenzophenone

CAS No.: 915095-86-2

EINECS No.: 619-596-4

Appearance: Solid

Molecular formula: C13H7ClFIO

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	360.55
Boiling point	415℃
Melting point	64-70℃
Density	1.752
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	/
Soluble	Soluble in chloroform (small amount), ethyl acetate
Water solubility	/
Color	Beige

 

 

Product Description:
(2 - Chloro - 5 - iodophenyl)(4 - fluorophenyl)methanone usually appears as a pale - yellow to light - brown crystalline solid. Structurally, it features a ketone group connecting a 2 - chloro - 5 - iodophenyl ring and a 4 - fluorophenyl ring. The chlorine, iodine, and fluorine atoms, all being electronegative halogens, confer unique electronic characteristics to the molecule. The chlorine atom in the 2 - chloro - 5 - iodophenyl group can take part in substitution reactions, for instance, nucleophilic substitution reactions when reacting with proper nucleophiles. The iodine atom, with its large size and relatively polarizable electron cloud, also contributes to the molecule's reactivity. It can be involved in reactions such as metal - catalyzed coupling reactions. The fluorine atom in the 4 - fluorophenyl group affects the electron density of the phenyl ring and can influence intermolecular forces due to its high electronegativity and small size. The ketone group (-C=O) is highly reactive and is likely to undergo nucleophilic addition reactions with various nucleophiles, including amines, alcohols, and organometallic reagents like Grignard reagents.

In terms of solubility, due to the non - polar nature of the two phenyl rings, it has poor solubility in water. However, it shows good solubility in common organic solvents like dichloromethane, chloroform, and ethyl acetate. In chemical reactions, the ketone carbonyl can be reduced to an alcohol using reducing agents such as sodium borohydride. The halogen - substituted phenyl rings can participate in reactions like cross - coupling reactions under appropriate conditions.

In the areas of organic synthesis and pharmaceutical research, (2 - Chloro - 5 - iodophenyl)(4 - fluorophenyl)methanone is of great significance. In organic synthesis, it acts as a valuable building block for creating more complex aromatic compounds. By reacting its different functional groups with diverse reagents, a wide variety of multi - functional molecules can be synthesized. In pharmaceutical research, it may serve as a potential intermediate for the synthesis of drugs with specific biological activities. Modifying the substituents on the phenyl rings or reacting the ketone group with different substances can potentially lead to the discovery of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry environment, away from light, heat, moisture, and strong oxidizing or reducing agents.

 

Application: 

It is an intermediate in the synthesis of epalegine

Package: 25kg/drum or bag

Storage: Under inert gas (nitrogen or Argon) at 2–8 °C

Executive Standards: International Standard.