2,6-Dihydroxy-3-methylpurine

Details:

Common name: 3-Methylxanthine

Category:Linagliptin intermediates

Other name: 2,6-Dihydroxy-3-methylpurine

CAS No.: 1076-22-8

EINECS No.: 214-058-1

Appearance: Solid

Molecular formula: C6H6N4O2

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	166.14
Boiling point	294.33°C (rough estimate)
Melting point	>300 °C (lit.)
Density	1.4434 (rough estimate)
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	pK1:8.10;pK2:11.3 (25°C)
Soluble	DMSO (slightly soluble, heated), methanol (slightly soluble)
Water solubility	Insoluble
Color	White

 

 

Product Description:
3 - Methylxanthine typically exists as a white to slightly yellowish crystalline powder. Structurally, it belongs to the xanthine family and features a purine - derived ring system with a methyl group attached at the 3 - position. This methyl substitution imparts unique properties to the molecule. The fused - ring structure, composed of a pyrimidine ring and an imidazole ring, gives it a planar and rigid conformation, which is crucial for its biological and chemical activities.

In terms of solubility, it has relatively low solubility in water but is more soluble in polar organic solvents such as ethanol and dimethyl sulfoxide (DMSO). It is stable under normal storage conditions, but elevated temperatures, strong acids, or bases can cause decomposition or chemical reactions. For example, in the presence of strong acids, it may undergo protonation reactions at the nitrogen atoms in the ring structure.

Pharmacologically, 3 - Methylxanthine is a mild stimulant. It acts by inhibiting phosphodiesterase enzymes, which leads to an increase in intracellular cyclic AMP levels. This, in turn, can have various effects on cells, including increased heart rate, enhanced smooth muscle relaxation in some tissues, and stimulation of the central nervous system. Clinically, it has been investigated for its potential use in treating certain respiratory disorders due to its ability to relax airway smooth muscles. In the food and beverage industry, it is a component in some natural products like tea and coffee, contributing to their stimulating effects. To maintain its quality and stability, 3 - Methylxanthine should be stored in a cool, dry place, away from direct sunlight and moisture.

 

Application: 

3 - Methylxanthine has several applications. In the medical field, it's investigated for treating certain respiratory disorders as it can relax airway smooth muscles. Pharmacologically, being a mild stimulant, it inhibits phosphodiesterase enzymes to increase intracellular cyclic AMP levels, affecting cell functions like increasing heart rate. In the food and beverage industry, as a component in tea and coffee, it contributes to their stimulating properties, providing consumers with a sense of alertness.

Package: 25kg/drum or bag

Storage: Sealed in dry, Room Temperature

Executive Standards: International Standard.