DL-Kawain TRANS-5,6-DIHYDRO-4-METHOXY 6-(2-PHENYLETHENYL)-2H-PYRAN-2-ONE
OEM Supply Superior Quality 99% Cytosine CAS 71-30-7
Basic Information:
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).
Cytosine reagent is used in a wide variety of research applications, as an enzyme-substrate or precursor of effector molecules such as cytosine sugars.
Product Name: | Cytosine |
Synonyms: | 4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE |
CAS: | 71-30-7 |
MF: | C4H5N3O |
MW: | 111.1 |
Molecular Formula | C14H14O3 |
Molar Mass | 230.26 |
Density | 1.15±0.1 g/cm3(Predicted) |
Melting Point | 142-148°C |
Boling Point | 432.6±45.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
Appearance | neat |
Color | Off-White to Pale Yellow |
BRN | 177877 |
Storage Condition | Amber Vial, -20°C Freezer, Under inert atmosphere |
Stability | Light and Moisture Sensitive |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from kava pepper. |
In vitro study | Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site. The β3N265M point mutation which has been previously shown to profoundly decrease anaesthetic sensitivity, also diminishes Kavain-mediated potentiation. |
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