(Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate

Details:

Common name: (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate

Category:Azilsartan & Candesartan Cilexetil intermediates

Other name: 2-ethoxy-1-((2'-((hydroxyamino)iminomethyl)(1,1'-biphenyl)-4-yl)methyl)-1h-benzimidazole-7-carboxylic acid methyl ester

CAS No.: 147403-65-4

EINECS No.: 692-067-3

Appearance: Solid

Molecular formula: C25H24N4O4

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	444.48
Boiling point	657.2±65.0 °C(Predicted)
Melting point	207-209°C
Density	1.29
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	6.77±0.69(Predicted)
Soluble	Soluble in chloroform (a little), DMSO (a little), methanol (a little)
Water solubility	/
Color	White

 

 

Product Description:
(Z)-Methyl 2 - ethoxy - 3 - ((2'-(N'-hydroxycarbamimidoyl)biphenyl - 4 - yl)methyl)-3H - benzo[d]imidazole - 4 - carboxylate typically presents as a white to off - white crystalline powder. Structurally, it features a benzoimidazole ring system. At the 2 - position, there is an ethoxy group, which imparts certain polarity and can participate in various chemical reactions. The 3 - position is substituted with a ((2'-(N'-hydroxycarbamimidoyl)biphenyl - 4 - yl)methyl) group. The biphenyl structure in this substituent contributes to the molecule's lipophilicity, while the N'-hydroxycarbamimidoyl group (-C(=NH)NHOH) is highly reactive and can be involved in processes such as hydrogen - bonding interactions and nucleophilic addition reactions. At the 4 - position, a carboxylate methyl ester group (-COOCH?) is present, which can be hydrolyzed under acidic or basic conditions to form the corresponding carboxylic acid or can participate in trans - esterification reactions.

In terms of solubility, it has low solubility in water due to the relatively non - polar nature of the biphenyl and benzoimidazole rings. However, it shows better solubility in polar organic solvents like ethanol, acetone, and dichloromethane. Under normal storage conditions, it is relatively stable. But exposure to strong acids, strong bases, or high temperatures can cause decomposition or chemical reactions. For example, in the presence of strong acids, the N'-hydroxycarbamimidoyl group may undergo protonation and subsequent chemical changes.

In the field of organic synthesis, it serves as a valuable intermediate. By reacting its multiple functional groups with different reagents, chemists can construct more complex and diverse molecules. In pharmaceutical research, it may act as a potential precursor for the synthesis of drugs with specific biological activities. The unique combination of functional groups in this compound offers possibilities for the development of novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from light, moisture, and strong oxidizing or reducing agents.

 

Application: 

It can be used as Azilsartan intermediate.

Package: 25kg/drum or bag

Storage:Under inert gas (nitrogen or Argon) at 2–8 °C

Executive Standards: International Standard.