Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Reference Information

trait	White or milky white powder.
Use	as a special polymer, polycarbopol non-calcium has the dual function of treating constipation and Diarrhea. And because the Poly carbopol calcium is a prodrug, the active ingredient is the Poly carbopol, under the action of gastric acid, the Poly carbopol calcium occurs decalcification ion exchange reaction, calcium is produced as a by-product, and therefore, polycarbopol calcium has the unique advantage of calcium supplementation while being treated. calcium polycarbophil was first developed by Abbott, USA, and has been widely used in Europe, America and Japan to relieve symptoms of IBS and constipation due to various causes.
pharmacological action	polycarbopol non-calcium has very unique biochemical properties, which can rapidly decalcify in acidic environment, poly-carbopol was formed. However, Poly-carbomer can absorb 10 times its own weight of water in an acidic environment, and the expansion rate increases significantly at pH> 4, in the neutral or weak alkaline environment can reach 60~100 times of their own weight. Animal experimental study showed that the calcium detachment rate in the stomach was more than 70% in 30min when the rats were given Poly-carbopol non-calcium, which was basically consistent with the calcium detachment curve of the in vitro experiment. It is proved that the water absorption of poly-Kappa non-calcium is affected by pH value, and the higher the pH value, the greater the water absorption.
mechanism of action	1. The main mechanism of action of Poly carbopol calcium in the intestine is:(1) water retention in the digestive tract. In the rat experiment, there was no effect on the water metabolism of the intestinal tube, and the water was maintained in the intestinal tube. (2) the regulation of the transport of the contents of the digestive tract. In experiments in mice and rats, in an animal model of enhanced intestinal delivery, administration of polycarbopol calcium found that gastrointestinal content delivery was inhibited. In an animal model of delayed intestinal delivery, administration of polycarbopol calcium was found to improve gastrointestinal content delivery. 2. Diarrhea inhibition and improvement of constipation effect: the Diarrhea model of mice, rats and dogs showed a Diarrhea reduction in the number of times and did not induce constipation. The constipation model in rats showed an ameliorative effect of increasing the amount of defecation, and Diarrhea was not induced. Pharmacokinetics in rats and dogs after oral administration of 14c-polycarbopol calcium or 14c-polycarbopol, blood radiomarker concentration determination test, urine/fecal excretion test, the results of whole body autoradiography, bile excretion test and in situ digestive tract absorption test in rats showed that the two compounds were not absorbed in the stomach, duodenum, jejunum, ileum and colorectal. In addition, there was no radioactive damage to any tissues when 14c-polycarbopol calcium was orally administered to rats, and no radioactivity was found in urine when 14c-polycarbopol calcium was orally administered to rats and dogs, the radioactivity of the drug is also almost completely absorbed by the feces. The above results show that the polycarbopol calcium is not absorbed by the digestive tract and is not metabolized by intestinal bacteria when it is orally administered, and is finally excreted out of the body through feces.
synthesis method	① firstly, magnesium sulfate and divinyl glycol were fully dissolved in water in a stirred reactor, stirring and heating to 76°C, to fully dissolve; ② Then add the mixture of acrylic acid and azobisisobutyronitrile Dropwise, stir evenly, heat preservation reaction for 3 hours; ③ clean with water at 76°C, get poly-carbopol; ④ fully stir the aqueous solution of poly-carbopol and calcium carbonate in the reaction kettle, and at the same time raise the temperature to 100°C for 6.5 hours; ④ put down the centrifugal dehydration, dry, pulverize, poly-carbo-non-calcium can be packaged if it is qualified by inspection. The yield of poly (carbo-non-calcium) synthesized by the above method is close to 100%, and the calcium content in the product quality item reaches 22%. Compared with the conventional synthesis method, significantly improve the yield and quality of the product.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.