CAS 54-62-6 Aminopterin Pharmaceutical
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Product Name: Aminopterin
CAS: 54-62-6
MF: C19H20N8O5
MW: 440.41
EINECS: 200-209-9
Melting point: 225 °C
Boiling point: 551.67°C
Density: 1.4378
Storage temp.: Inert atmosphere,Room Temperature
Appearance: White Powder
Description:
Aminopterin is an amino derivative of folic acid, which was once used as an antineoplastic agent in the treatment of pediatric leukemia. In the 1950's its production was discontinued in favor of methotrexate, which is less potent but less toxic. Off label, aminopterin has also been used in the treatment of psoriasis. Clinicians need to be aware of the characteristic teratologic effects of aminopterin and methotrexate.
Use:
A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
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