Details:

Our advantage:

1. High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Molecular Formula	C22H22FN3O3
Molar Mass	395.43
Density	1.280±0.06 g/cm3(Predicted)
Melting Point	227-235°C
Solubility	Soluble in water (<1 mg/ml at 25 °C), DMSO (2 mg/ml at 25 °C), ethanol (<1 mg/ml
Appearance	Solid
Color	White to Off-White
Merck	14,5296
pKa	7.5(at 25℃)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.592
Physical and Chemical Properties	Crystallization from 4-methyl-2-pentanone, melting point 227-235 °c. Solubility (g/100ml): Water 0.001, ethanol 0.038, dimethylformamide 2.34. pKa 7.5.
Use	For the treatment of hypertension medication

Clinical application	1. Treatment of pregnancy-induced hypertension syndrome and Preeclampsia: Although ketanserin is an antihypertensive drug, however, there are few clinical reports on the treatment of essential hypertension, and the use of ketostilbene in pregnancy-induced hypertension syndrome, preeclampsia and HELLP syndrome (hemolysis, elevated liver enzymes and thrombocytopenia syndrome) the prevention and treatment of clinical observation reported more. Most reports suggest that ketanserin has certain preventive and therapeutic effects on pregnancy-induced hypertension, preeclampsia and HELLP syndrome. According to the majority of clinical observations, ketanserin for the majority of pregnancy-induced hypertension syndrome, preeclampsia and other pregnancy-induced hypertension complications have a better therapeutic effect, and has not yet found its significant adverse effects on the fetus. As for some patients with ketoxylin efficacy is not ideal, should be further beyond the pharmacokinetic reasons. 2. Application of coronary artery balloon angioplasty coronary artery balloon angioplasty is a common surgical method for the treatment of myocardial ischemia caused by tubular artery stenosis. But in the coronary artery balloon angioplasty because of the stenosis of the coronary artery into the coronary stent, sometimes immediately the original stenosis of the distal coronary artery contraction, causing myocardial ischemia, it is speculated that this coronary artery constriction may be caused by 5-HT. The experimental results not only indicate that ketanserin has the effect of preventing myocardial ischemia in coronary artery balloon angioplasty, but also suggest that ketanserin may have a new application in the treatment of myocardial ischemia.
Use	1. Treatment of Cushing's syndrome: because the formation of thalamic-pituitary Cushing's syndrome is associated with central 5-HT neurons. Thus, attempts have been made to treat pituitary Cushing's syndrome with ketanserin. Subjects were given ketanserin 40-80 mg/d, and urinary cortisol and adrenocorticotropic hormone (ACTH) were monitored. Therefore, it is considered that the treatment of Cushing's syndrome with ketoranserin may have a certain effect, but the duration of its efficacy and the number of patients with marked effect are limited. But after all, this experiment provides a new idea for the pathogenesis and treatment of thalamic-pituitary Cushing's syndrome. 2. Treatment of leg and foot ulcers in diabetic patients: diabetic leg and foot ulcers are a complication of diabetes that is difficult to treat, the patient was at risk for amputation. Topical application of 2% ketosolin ointment has been tried to treat diabetic leg and foot ulcers. Its therapeutic mechanism may be related to blocking α receptor and dilating blood vessels to improve local circulation. The results of this study not only provide a new therapeutic approach for the treatment of leg and foot ulcers in diabetic patients, but also expand the range of clinical applications of ketanserin. selective antagonists of serotonin s2-receptors, without agonistic activity, with weak αl-and H1-antagonistic activity, but without effect on other receptors. For the control of mild, moderate or severe hypertension, can also be used to control acute hypertension attack, such as before or after surgery and maternal preeclampsia. medication for hypertension
production method	Method 1: condensation of compound (I) with 4-(4-fluorobenzoyl) piperidine, ketanserin was obtained. Method 2: compound (II) and 4-(4-fluorobenzoyl) piperidine, sodium carbonate were heated in 5-methyl -2-pentanone to give ketorin.

Product Packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)

 Storage：

Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Delivery：

Usually within3-5 working days after full payment.

transport：

EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA

DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service; 

Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;

For high value products, please select air shipping and DHL express for safe;

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

 

Packing:  
  1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg); 

  2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg). 

  3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg). 

P.S.: we accept packaging customization. 

  
Delivery:   

  1. Stock products are normally shipping within 3 working days.  

  2. For rush delivery, please contact our sales team for particular arrangement. 

Shipping Details: 
  1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker. 

  2. Shipping details & shipping documents will be provided and sent by email. 

  3. We keep tracking the shippment until clients well received. 

  4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently. 

About us

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

2.How do you control the quality   
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   

3. How long is lead time   
We deliver goods within 3 days for small order, 7-10 days for bulk order.   

4. Where is your factory located  How can I visit the factory   
 Our factory located in HEBEI, China.

5. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 

6. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  

7. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

8. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

9. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.