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Ethanol,2,2',2''-nitrilotri- (8CI) 2,2',2''-Nitrilotriethanol 2-[Bis-(2-hydroxy-ethyl)-amino]-ethanol
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(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is an organic compound commonly abbreviated as TMSA. The following is an introduction to its nature, use, preparation and safety information:
Nature:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a colorless liquid with good solubility in water and most organic solvents. Its molecular formula is C9H16O4 and its molecular weight is 188.22g/mol. It has a density of about 0.995 g/mL and a boiling point of about 198-200 ° C.
Use:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a commonly used organic synthesis intermediate. It can be used as a substrate, reducing agent and ligand for chiral catalysts. In addition, it can also be used to prepare organic compounds such as drugs, fragrances and dyes.
Method: The preparation of
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER usually involves specific synthetic routes and chemical reactions. A common synthetic method is to obtain (R)-2-methyl-3-methylthiopropionate by oxidation of methyl propyl mercaptan (MPTS), followed by methyl esterification with acetic anhydride to obtain the desired product. Specific synthesis steps and conditions can be adjusted according to needs and experimental conditions.
Safety Information:
(R)-2-METHYLSUCCINIC ACID 4-TERT-BUTYL ESTER is a chemical, so you need to pay attention to safety when using and handling it. It is combustible and should be kept away from fire and flame. Wear protective gloves, goggles and protective clothing during operation. Avoid contact with skin, eyes and respiratory tract. In case of accidental contact, rinse immediately with water and seek medical assistance. In addition, it should be kept away from children and animals, stored in sealed containers, and placed in a cool, dry place.
Molecular Formula | C6H15NO3 |
Molar Mass | 149.19 |
Density | 1.124 g/mL at 25 °C (lit.) |
Melting Point | 17.9-21 °C (lit.) |
Boling Point | 190-193 °C/5 mmHg (lit.) |
Flash Point | 365°F |
Water Solubility | soluble |
Solubility | H2O: 1M, clear, colorless |
Vapor Presure | 0.01 mm Hg ( 20 °C) |
Vapor Density | 5.14 (vs air) |
Appearance | Oily Liquid |
Specific Gravity | 1.125 (20/20℃) |
Color | Clear colorless to slightly yellow |
Odor | Mild ammoniacal. |
Exposure Limit | ACGIH: TWA 5 mg/m3 |
Maximum wavelength(λmax) | ['λ: 280 nm Amax: 0.1'] |
Merck | 14,9665 |
BRN | 1699263 |
pKa | 7.8(at 25℃) |
PH | 10.5-11.5 (25℃, 1M in H2O) |
Storage Condition | Store at RT. |
Sensitive | Air Sensitive & Hygroscopic |
Explosive Limit | 3.6-7.2%(V) |
Refractive Index | n20/D 1.485(lit.) |
Physical and Chemical Properties | It is a colorless transparent viscous liquid at room temperature. Hygroscopicity and ammonia odor, alkaline, irritating. Melting point 21.2 ℃, boiling point 360℃, flash point 193 ℃, relative density (d420)1.1242, refractive index (nD20)1.4852. Miscible in water, ethanol and acetone, slightly soluble in ether, benzene and carbon tetrachloride. |
Use | It is used as an additive in the polymerization of nitrile rubber, a concrete Accelerator, an oil emulsifier, and also used for cyanide-free electroplating. |
Overview | triethanolamine triethanolamine also known as trihydroxyethylamine, aminotriethanol. Colorless oily liquid, ammonia odor, easy to absorb water, open air and in the light to become brown. At low temperature, it is a colorless or light yellow cubic crystal. The melting point is 21.2 ℃, the boiling point is 335.4 ℃, 277 ℃(19.950kPa), 206~207 ℃(1.995kPa), the relative density is 1.1242, the refractive index is 1.4852. Kb = 2.5 x 10-10. 0.1mol/L aqueous solution pH was 10.5. Miscible with water, methanol and acetone. Soluble in benzene, ether, micro-soluble carbon tetrachloride, n-heptane. Strong bases, combined with protons, can be used for condensation reactions. In analytical chemistry, triethanolamine can be used as a stationary liquid for gas-liquid chromatography (the highest temperature is 75 ℃, and the solvent is methanol and ethanol) for separating pyridine and methyl substituents. In the analysis of Complexometric titration, can be used as a masking agent for interfering ions, such as in the solution of pH = 10, using EDTA titration of magnesium, zinc, cadmium, calcium, nickel plasma, the titanium, aluminum, iron, tin plasma can be masked with the reagent. In addition, with hydrochloric acid can also be prepared into a certain pH buffer solution. triethanolamine is mainly used in the manufacture of surfactants, liquid detergents, cosmetics, etc. It is one of the components of cutting fluid and antifreeze. In the polymerization of nitrile rubber as an activator, natural rubber and synthetic rubber vulcanization activator. Can also be used as oil, wax, pesticide and other emulsifiers, cosmetics moisturizing agent, stabilizer, textile softener, lubricating oil anti-corrosion additives. Triethanolamine can absorb gases such as carbon dioxide and hydrogen sulfide, and can remove acid gas in the purification of industrial gases such as coke oven gas. EDTA titration method is commonly used as a masking agent. The allowable concentration in air is 3 μg/g. |
external use in dermatology | at present, the external use of biafen, a drug commonly used in dermatology departments of many hospitals to treat burns and skin wounds, is mainly composed of triethanolamine, triethanolamine can play a dual role of cleaning and drainage through the principle of penetration and capillary action, can increase the skin blood flow rate, help discharge exudate, and can also change the ratio between interleukin I and interleukin VI, stimulates fibroblast proliferation, increases collagen synthesis. Clinical for the treatment of radiation therapy caused by secondary erythema, I, II degree burn and not yet infected skin trauma. (1) skin damage caused by radiotherapy: it is recommended to apply 2~3 times a day, with equal intervals for each application, and gently massage to make skin absorption. (2) second degree burns and other skin wounds: after cleaning the wound, apply a thick layer of drug on the surface of the wound, and repeat the application to make the wound have a sufficient amount of drug. If necessary, please use wet compress. Do not use dry absorbent compress. (3) I Degree Burn: apply a thick layer until the skin no longer absorb the drug, and gently massage. 2-4 times a day. |
Early strength agent | triethanolamine is a commonly used early strength agent in China's cement industry, the role of early strength agent is to accelerate the hydration process of cement in the presence of liquid phase in concrete, improve the early strength, although triethanolamine does not change the hydration products of cement, however, it can strengthen the activity of colloid generated by cement hydration, generate pressure on the surrounding, block the capillary channel, and intensify the adsorption, wetting and particle dispersion, to promote the formation of calcium sulphoaluminate hydrate reaction between C3A and gypsum, can improve the concrete density, impermeability and frost resistance, the role of early strength and improve the strength. When used in combination with inorganic salt materials, due to the hydration of cement itself and the reaction of inorganic salt and cement, it can play a catalytic role, so that the early strength effect is particularly significant. |
Use | GB 2760-96 provides that the permitted use of food processing aids is limited to GMP. used as a detergent for removing carbon dioxide or hydrogen sulfide from a gas. Esters of triethanolamine and higher fatty acids are widely used as detergents, emulsifiers, humectants and lubricants, and also in the formulation of cosmetic balms. Triethanolamine is also used as a preservative and water repellent, Analytical reagents and solvents. As an activator in the polymerization of nitrile rubber, it can also be used as an emulsifier, stabilizer and softener for oils and waxes under acidic conditions. It is one of the components of synthetic fiber spinning finish. It is used as an additive in the polymerization of nitrile rubber, a concrete Accelerator, an oil emulsifier, and also used for cyanide-free electroplating gas chromatography stationary liquid (the highest temperature is 75 ℃, the solvent is methanol, ethanol), separation and analysis of oxygen-containing, nitrogen-containing compounds and aqueous samples. Complexing agents. Metal masking agents. Platinum and palladium were titrated. Colorimetric Determination of manganese. Determination of tin, antimony and manganese. Absorption of carbon dioxide and carbon disulfide and other alkaline gases. Emulsifiers. Solvent. Corrosion inhibitors. gas chromatography stationary liquid (the highest temperature is 75 ° C., the solvent is methanol, ethanol), separation and analysis of oxygen-containing, nitrogen-containing compounds and aqueous samples. Complexing agent, metal masking agent, titration of palladium and platinum, Colorimetric Determination of manganese, determination of tin, antimony. Absorbs odors such as carbon dioxide and carbon disulfide. Emulsifiers, solvents, corrosion inhibitors. |
production method | ethylene oxide and ammonia water are fed into the reactor at a reaction temperature of 30-40 ℃ and a reaction pressure of 70.9-304kPa, after dehydration and concentration at 90-120 ° C., the mixture of mono-, di-and triethanolamine is produced by condensation reaction and sent to three vacuum distillation columns for vacuum distillation, and fractions are cut off according to different boiling points, A final product of monoethanolamine, Diethanolamine and triethanolamine with a purity of 99% is obtained. In the reaction process, if the proportion of ethylene oxide is increased, the proportion of di-and triethanolamine is increased, and the yield of di-and triethanolamine can be increased. It is obtained by condensation reaction of ethylene oxide and ammonia water at 30-40 ° C. Under a pressure of 71-304 kPa, wherein the molar concentration ratio of ethylene oxide to ammonia is about 2.0. After the reaction, the reaction mixture was subjected to vacuum distillation in a rectification column, and a fraction in the vicinity of 360 ° C. Was obtained. |
category | flammable liquid |
toxicity grade | low toxicity |
Acute toxicity | oral-rat LD50: 8000 mg/kg; Oral-mouse LD50: 5846 mg/kg |
stimulation data | Skin-rabbits 560 mg/24 h mild; eye-rabbit 20 mg severe |
flammability hazard characteristics | flammable in open flame, high temperature, strong oxidant; combustion emission toxic nitrogen oxide smoke |
storage and transportation characteristics | The package is complete, light and light unloading; The warehouse is ventilated, away from open flame, high temperature, acid, separate storage of copper and aluminum |
fire extinguishing agent | foam, dry powder, carbon dioxide, sand |
Occupational Standard | TWA 5 mg/m3; Tel 10 mg/m3 |
spontaneous combustion temperature | 600 ° F. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging:
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage:
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery:
Usually within3-5 working days after full payment.
transport:
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.
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