VX-770 873054-44-5

VX-770 873054-44-5
VX-770 873054-44-5
VX-770 873054-44-5
VX-770 873054-44-5
VX-770 873054-44-5

VX-770 873054-44-5

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 15.0000 -50.0000
  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,D/A,D/P,T/T

Keywords

Kalydeco Ivacaftor N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

Quick Details

  • Appearance:Solid
  • Application:medical intermediate
  • PackAge:5mg/vial, 10 vials per box
  • ProductionCapacity:3000|Kilogram|Month
  • Storage:2-8°C
  • Transportation:EMS,DHL,?TNT,?UPS?,FEDEX,?BY?AIR,?BY?SEA DHL?Express,?FedEx?and?EMS?for?quantity?less?than?50KG,?usually?called?as?DDU?service;? Sea?shipping?for?quantity?over?500KG;?And?air?shipping?is?available

Superiority:

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details:

Molecular Formula C24H28N2O3
Molar Mass 392.49
Density 1.187
Melting Point 212-215°C
Boling Point 550.4±50.0 °C(Predicted)
Flash Point 286.7°C
Solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Vapor Presure 1E-12mmHg at 25°C
Appearance Solid
Color White to Light Brown
pKa 11.08±0.23(Predicted)
Storage Condition Refrigerator
Refractive Index 1.605
Use Ivacaftor (VX-770) is an enhancer of cystic fibrosis transmembrane conduction regulator (CFTR), which targets G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively.
In vitro study Ivacaftor(10 μm) significantly increased forskolin-stimulated Cl in Fisher rat thyroid (FRT) cells expressing CFTR mutant G551D
In vivo study Ivacaftor acts on cystic fibrosis subjects aged 6 to 11 carrying the G551D mutation and has completed Phase III study.

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