3:PN: WO0005255 PAGE: 8 claimed sequence Annexin-1 (2-26) (human) Lipocortin-1 (2-26)
Annexin A1 (AnxA1) N-terminal-derived peptide, also known as Ac2-26, mimics the antiinflammatory effects of AnxA1. Ac2-26 can activate all three formyl peptide receptor family members FPR, FPR-like (FPRL)1 and FPRL2 at similar concentations. It represents the first endogenous ligand for FPRL2. In myocardial ischemia-reperfusion injury experiments the peptide showed cardioprotective effects. Understanding the underlying mechanism may help developing novel therapeutics for acute cardioprotection.
Our peptide has key advantages. It enables precise sequence design for specific needs, offers high purity via advanced methods, and provides flexibility in length, modification, and quantity, crucial for diverse applications.
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