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L-Lysine,N2-[N2-[N-(N-acetylmuramoyl)-L-alanyl]-D-a-glutaminyl]-N6-(1-oxooctadecyl)- 1: PN: WO2009033811PAGE: 103 claimed sequence DJ 7041
Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2, also called Romurtide, Muroctasin, MDP-Lys(L 18), Ac-muramyl-Ala-D-Isogln-Lys(stearoyl)-OH. The investigation of the adjuvant activity of Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH2 on humoral and cellular immune responses showed that it augments the mitogenic responses of splenic lymphocytes to phytohemagglutinin and lipopolysaccharide and the formation of antibodies to sheep erythrocytes in mice. In addition, it potentiated polyclonal B cell activation in vivo and in vitro.
Our peptide has key advantages. It enables precise sequence design for specific needs, offers high purity via advanced methods, and provides flexibility in length, modification, and quantity, crucial for diverse applications.
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