AZD5363 1143532-39-1

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 30.0000 -80.0000

1 Kilogram

FOB Price:USD 30.0000 -80.0000

Min.Order :1 Kilogram
Purity: >99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

CAPIVASERTIB (S)-4-Amino-N-(1-(4-chlorophenyl) 3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide

Quick Details

Appearance:solid
Application:Used in pharmaceutical intermediates
PackAge:1 kg/bag; 25 kg/carton
ProductionCapacity:3000|Kilogram|Month
Storage:Room Temprature
Transportation:according to your needs

Superiority:

Our Advantage

Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.

Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.

24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.

High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.

Details:

Molecular Formula	C21H25ClN6O2
Molar Mass	428.92
Density	1.381
Melting Point	161-164°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Off-White to Pale Beige
pKa	13.93±0.50(Predicted)
Storage Condition	Refrigerator
In vitro study	AZD5363 is a potent inhibitor of Akt, inhibiting Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. The activation of PIK3CA mutation, the loss or inactivation of the tumor suppressor gene PTEN, or the amplification of HER2 all have a significant relationship with AZD5363. Furthermore, a correlation between the RAS mutational status of the cell lines and the anti-azd5363 can also be seen. AZD5363 inhibited phosphorylation of AKT substrates in cells with a titer of about 0.3~0.8 μm. AZD5363 inhibited cell proliferation in 41 of 182 solid and hematologic tumor cell lines with a titer of <3 μm.
In vivo study	AZD5363 was orally administered to nude mice at a dose of 100,300 mg/kg to reduce the phosphorylation of PRAS40, GSK3β, and S6 in the transplanted tumor of BT474c in a dose-and time-dependent manner, it also reversibly increases blood glucose concentration and reduces 2 [