LY 2784544 1229236-86-5

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 30.0000 -80.0000

1 Kilogram

FOB Price:USD 30.0000 -80.0000

Min.Order :1 Kilogram
Purity: >99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

LY 2784544 3-[(4-Chloro-2-fluorophenyl)methyl]- 2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine

Quick Details

Appearance:solid
Application:Used in pharmaceutical intermediates
PackAge:1 kg/bag; 25 kg/carton
ProductionCapacity:3000|Kilogram|Month
Storage:Room Temprature
Transportation:according to your needs

Superiority:

Our Advantage

Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.

Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.

24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.

High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.

Details:

Molecular Formula	C23H25ClFN7O
Molar Mass	469.94
Density	1.45
Solubility	DMSO 94 mg/mL (200.02 mM); Water <1 mg/mL (<1 mM); Ethanol 9 mg/mL (19.15 mM)
pKa	14.12±0.10(Predicted)
Storage Condition	-20℃
MDL	MFCD20482143
Use	A selective inhibitor of JAK2 mutant V617F.
In vitro study	LY2784544 also inhibited IL-3-activated wild-type JAK2 with an IC50 of 2.26 µm. In the proliferation experiment, LY2784544 has anti-proliferative activity with an IC50 of 68 nM in cells driven by JAK2 V617F, while it has an IC50 of 1356 nM in cells driven by wild-type JAK2, when acting on jak3-driven cells, the IC50 was 940 nM.
In vivo study	LY2784544 significantly inhibited STAT5 phosphorylation in Ba/F3-JAK2 V617F-GFP xenografts with a threshold effective dose 50 (TED50) of 12.7 mg/kg. LY2784544 acts on the MPN model induced by JAK2 V617F and also reduces the tumor burden V617F-GFP Ba/F3-JAK2, with a TED50 of 13.7 mg/kg after oral treatment. LY2784544 was orally applied to the spleen of SCID mice and had no effect on CD71/Ter119 positive erythroid progenitor cells.