1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

Details:

Common name: 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

Category:Pharmaceutical raw materials

Other name: 5H-1-Benzazepin-5-one, 1-(4-aMino-2-Methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-

CAS No.: 137977-97-0

EINECS No.: 1592732-453-0

Appearance: Solid

Molecular formula: C18H17ClN2O2

 

Brand Name: Colorcom

Shelf Life: 2 Years

Place of Origin: China

 

Product Specification:

Molecular Weight	328.79
Boiling point	565.4±50.0 °C(Predicted)
Melting point	186-189°C
Density	1.320
Purity	≥99.0%
PH	/
Acidity coefficient (pKa)	2.28±0.10(Predicted)
Soluble	Soluble in DMSO (a little), methanol (a little)
Water solubility	/
Color	Off-white to light yellow

 

 

Product Description:
1-(4 - Amino - 2 - methylbenzoyl)-7 - chloro - 1,2,3,4 - tetrahydro - 5H - 1 - benzazepin - 5 - one commonly presents as a white to off - white crystalline powder. Structurally, it features a 1 - benzazepine ring system that has been reduced to a tetrahydro form, with a carbonyl group at the 5 - position, which imparts certain reactivity and polarity to the molecule. At the 7 - position, a chlorine atom is attached, influencing the compound's physical and chemical properties. The benzazepine ring is fused with a benzene ring, contributing to the overall rigidity and lipophilicity of the molecule.?

On one side of the benzazepine ring, there is a 4 - amino - 2 - methylbenzoyl group. The amino group (-NH?) in the 4 - position of the benzene ring of this benzoyl moiety is a nucleophilic site, capable of participating in reactions such as acylation, alkylation, and condensation reactions. The methyl group in the 2 - position of the same benzene ring can affect the electron density of the ring and thus influence the reactivity of the adjacent functional groups. The carbonyl group of the benzoyl moiety can also engage in reactions like nucleophilic addition.?

In terms of solubility, it has low solubility in water due to the relatively non - polar nature of the large ring structures. However, it shows better solubility in polar organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and N,N - dimethylformamide (DMF). Under normal storage conditions, it is relatively stable. But exposure to strong acids, strong bases, or high temperatures can cause decomposition or chemical reactions. For example, in the presence of strong acids, the amino group may get protonated, altering the compound's reactivity.?

In the field of organic synthesis, this compound serves as an important intermediate. Its multiple functional groups allow for the construction of more complex molecules through reactions with different reagents. In pharmaceutical research, it may have potential applications as a building block for drugs. The unique combination of functional groups may confer specific biological activities, and modifications to the structure can be explored to develop novel bioactive substances. To maintain its quality and reactivity, it should be stored in a cool, dry place, away from light, moisture, and strong oxidizing or reducing agents.

 

Application: 

1-(4 - Amino - 2 - methylbenzoyl)-7 - chloro - 1,2,3,4 - tetrahydro - 5H - 1 - benzazepin - 5 - one is mainly used as a key intermediate in organic synthesis. Its diverse functional groups enable the creation of complex molecules through reactions like acylation, alkylation, and condensation. In pharmaceutical research, it may act as a building block for drugs, with its unique structure potentially conferring specific biological activities for further exploration in developing novel bioactive compounds.

Package: 25kg/drum or bag

Storage: -20°C Freezer

Executive Standards: International Standard.