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1,4-Naphthalenedione,2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-, trans- Acuvel Atavaquone
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Molecular Formula | C22H19ClO3 |
Molar Mass | 366.84 |
Density | 1.349±0.06 g/cm3(Predicted) |
Melting Point | 216-2190C |
Boling Point | 535.0±50.0 °C(Predicted) |
Flash Point | 277.348°C |
Solubility | DMSO: >10mg/mL |
Vapor Presure | 0mmHg at 25°C |
Appearance | powder |
Color | yellow |
Maximum wavelength(λmax) | ['494nm(aq. Buffer)(lit.)'] |
Merck | 14,866 |
pKa | 5.01±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.653 |
Physical and Chemical Properties | Crystallized from acetonitrile, melting point 216-219 ℃. |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Atovaquone (atavaquone) is a naphthalene compound. Atovaquone is hydroxy-1, 4-naphthoquinone, a ubiquinone analog, which has activity against Pneumocystis. Atovaquone is an antigenic insect mitochondrial electron transfer inhibitor, an antimalarial agent, an anti-Pneumocystis, and is also used in the treatment of toxoplasmosis. It works by interacting with Rieske iron-sulfur proteins and cytochrome B in the ubiquinone oxidation pocket, inhibiting the cytochrome bc(1) complex. |
In vivo study | Atovaquone is a unique naphthoquinone with a broad spectrum of antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective for the treatment and prevention of malaria in combination with proguanil, and it is effective for the treatment of babesiosis in combination with azithromycin. |
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