Gabapentin hydrochl...

Gabapentin hydrochloride 60142-96-3
Gabapentin hydrochloride 60142-96-3
Gabapentin hydrochloride 60142-96-3
Gabapentin hydrochloride 60142-96-3
Gabapentin hydrochloride 60142-96-3

Gabapentin hydrochloride 60142-96-3

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 15.0000 -50.0000
  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : L/C,D/A,D/P,T/T

Keywords

1-(Aminomethyl)cyclohexaneacetic acid Gabapentin Neurontin

Quick Details

  • Appearance:Reddish brown powder
  • Application:Used as an intermediate in the drug telmisartan
  • PackAge:5mg/vial, 10 vials per box
  • ProductionCapacity:3000|Kilogram|Month
  • Storage:2-8°C
  • Transportation:EMS,DHL,?TNT,?UPS?,FEDEX,?BY?AIR,?BY?SEA DHL?Express,?FedEx?and?EMS?for?quantity?less?than?50KG,?usually?called?as?DDU?service;? Sea?shipping?for?quantity?over?500KG;?And?air?shipping?is?available

Superiority:

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details:

Molecular Formula C9H17NO2
Molar Mass 171.24
Density 1.058±0.06 g/cm3(Predicted)
Melting Point 162°C
Boling Point 314.4±15.0 °C(Predicted)
Flash Point 9℃
Water Solubility H2O: 10 mg/mL
Solubility H2O: 10mg/mL
Vapor Presure 6.32E-05mmHg at 25°C
Appearance solid
Color off-white
Merck 14,4319
BRN 2359739
pKa pKa1 (25°) 3.68; pKa2 10.70
Storage Condition 2-8°C
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Refractive Index 1.484
Physical and Chemical Properties Melting Point: 162°C
In vitro study Gabapentin concentration-dependent inhibition of potassium (+)-induced increases in [Ca(2 )] in fura-2-loaded human neocortical synaptosomes, the IC 50 is 17 mM and the maximum suppression is 37%. Gabapentin binds to the α2 delta subunit of the calcium channel to selectively attenuate the Ca(2) channel of the (2) internal flow of the P / Q type of the Ca presynaptic induced by depolarization, this will result in a decrease in the release of glutamate/aspartate from the excitatory amino acid nerve terminals to the noradrenergic nerve terminals by AMPA heteroreceptors. In rat cortical astrocytes and synaptosomes, Gabapentin causes production of cytoplasmic alterations and changes in extracellular concentrations of several amino acids, including L-leucine, L-valine, and L-phenylalanine, it is assumed to be an effect of pharmacological significance. In GABA B receptors constitutively expressing heterodimers of gb1a-GB2 subunits, Gabapentin reduces potassium-evoked calcium influx through voltage-gated calcium channels. In GABA-positive rat spinal dorsal horn neurons, Gabapentin increases N-methyl-D-aspartate (NMDA)-evoked currents in the presence of protein kinase C, possibly by increasing the glycine sensitivity of the NMDA receptor complex. In rat dorsal root ganglion neurons, Gabapentin enhances delayed allosteric activity of indeterminate voltage-activated potassium currents.
In vivo study In rats, Gabapentin dose-dependently (10-100 mg/kg, oral) blocks the effects of static and dynamic allodynia.

View All
Visit Store

You Might Also Like

Related Searches

Contact Supplier

Confirm to collect the product to my collection?

OKCancel

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View