CORTEXOLONE

Details:

Description of Cortexolone from Wuhan Fortuna Chemical Co.,Ltd

Basic Information of Cortexolone
Product Name	Cortexolone
CAS NO.	152-58-9
Apperance	White crystalline powder
Assay	99.5%
Pacakge	1kg/Foil Bag, 25kg/ Box/carton
MOQ	1kg
Storage	Cool and dry place
Shelf Life	2 Years
Brand	Fortunachem

Specifications(COA) of Cortexolone CAS 152-58-9

Items	Specifications	Results
Appearance	White to off white crystalline or crystalline powder	White crystalline powder
Solubility	Freely Soluble in water	Conforms
Identifacation	HPLC:The retention time of the main peak of the solution should be consistent with the retention time of the main peak of the reference solution	Conforms
Water	≤0.5%	0.07%
Related substances	A Impurity A ≤2.0%	0.07%
	Other single impurity ≤1.0%.	0.66%
	Total impurities ≤5.0%	1.78%
Assay	≥95.0%	99.5%
Conclusion	Complies to the Enterprise Standard

Introduction of Cortexolone (11-deoxycortisol or Reichstein’s Substance S) is a steroid hormone precursor in cortisol biosynthesis. Produced from 17α-hydroxyprogesterone via 21-hydroxylase, it is converted to cortisol by 11β-hydroxylase (CYP11B1). Clinically, elevated cortexolone levels indicate 11β-hydroxylase deficiency, a form of congenital adrenal hyperplasia (CAH) causing hypertension and androgen excess. It is structurally identical to cortisol but lacks the 11β-hydroxyl group. Used diagnostically in the metyrapone test (assesses adrenal function by blocking cortisol synthesis), it also aids research on glucocorticoid regulation and endocrine disorders. Inhibiting its conversion (e.g., with metyrapone) helps manage cortisol overproduction in conditions like Cushing’s syndrome.

Application of Cortexolone (also known as 11-deoxycortisol or Reichstein's Substance S) is a steroid hormone precursor involved in the biosynthesis of cortisol, a critical glucocorticoid produced in the adrenal cortex. Here's a concise overview:

Key Features:

1. Role in Steroidogenesis:

Acts as an intermediate in the cortisol synthesis pathway.

Formed from 17α-hydroxyprogesterone via the enzyme 21-hydroxylase.

Converted to cortisol by 11β-hydroxylase (CYP11B1), which adds a hydroxyl group at the 11β position.

2. Clinical Significance:

Diagnostic Marker: Elevated levels occur in 11β-hydroxylase deficiency, a form of congenital adrenal hyperplasia (CAH), leading to hypertension and androgen excess.

Metyrapone Test: Used to assess adrenal function; metyrapone inhibits 11β-hydroxylase, blocking cortisol synthesis and causing cortexolone accumulation.

3. Structure:

Structurally similar to cortisol but lacks the 11β-hydroxyl group.

4. Research & Pharmacology:

Studied in endocrine disorders and steroid metabolism research.

Inhibitors of its conversion (e.g., metyrapone) treat conditions like Cushing’s syndrome by modulating cortisol production.

Summary:

Cortexolone is a pivotal intermediate in cortisol production, with diagnostic and research applications in adrenal disorders. Its measurement aids in identifying enzyme deficiencies and understanding glucocorticoid regulation.

FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q	Can I get a sample for free ?
A	For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q	How to confirm the product quality before placing orders ?
A	Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q	What is the payment you accept?
A	For small and low value order, we accept CreditCard, MaterCard,VISA, and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q	What is your shipment way ?
A	For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q	How long is your after-sales service?
A	We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q	How do you treat quality complaint ?
A	We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is  the members of Hubei E-commerce Chamber.

 

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

 

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

 

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Cortexolone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Cortexolone.