Orlistat)

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Quick detail:

Product Name: Orlistat

CAS: 96829-58-2

MF: C29H53NO5

MW: 495.73

Appearance: White crystalline powder

Description

Orlistat is a white to off-white crystalline powder. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat has no pKa within the physiological pH range.

Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. In the intestine, an enzyme called lipase (produced primarily by the pancreas) breaks apart fat in food so that it can be absorbed into the body. 

Orlistat blocks the action of lipase and thereby prevents the breakup and absorption of fat. Orlistat blocks absorption of about 25% of the fat in a meal. The unabsorbed fat is excreted in the stool. The FDA approved Orlistat by prescription in 1999. a lower dose formulation of orlistat, was approved for purchase without a prescription "over the counter" in 2007.

Dosage

Orlistat,The patient's diet should be balanced, the low-calorie, about 30% of heat energy from fat, food should be rich in fruits and vegetables.Fat, carbohydrates and protein intake should be actually three meals per day.There is no evidence to suggest that more than 120 mg three times a day/time can enhance curative effect.No adjustment of dosage is needed for old people.

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