CasNo.110351-91-2,Exatecan Impurity;110351-91-2,(110351-91-2) Suppliers

10 Milligram	FOB Price: USD 10.0000

Min.Order :10 Milligram
Purity: 99%+ HPLC
Payment Terms : T/T

Keywords

Exatecan Impurity 110351-91-2 C13H13NO5

Quick Details

Appearance:White to off white powder
Application:experiment research
PackAge:Food bags, aluminum foil bags
ProductionCapacity:5000|Gram|Year
Storage:cool and dry
Transportation:DHL,EMS,TNT,UPS,EMS,by air,by sea;

Superiority:

We supply over 20000 types of spot impurity reference materials, with sufficient supply and same day delivery to meet customers' urgent needs for replenishment at any time. The company has its own research and development center and laboratory, and the team members have over ten years of experience in developing drug impurity reference standards. Our website www.molcoo.com covers over 98% of cutting-edge generic drug projects, with complete structural formulas that greatly save customers time in impurity structure analysis and inference. All products undergo strict quality control testing and provide relevant information such as COA, H-NMR, C-NMR, MS/GC-MS, HPLC/GC purity, QNMR quantification, TGA thermogravimetric analysis, IR infrared, UV ultraviolet, two-dimensional (COSY, NOESY, HMBC, HMQC), etc. These structural confirmation spectra ensure quality and reliability. Our products have a wide range of categories, fast delivery time, good quality, and low prices, which can quickly solve various customer needs such as replenishment and consistency evaluation.

Details:

Exatecan Impurity

NOTE！

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com

NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com
Product Information
- Product Code: E068004
- English Name: Exatecan Impurity 4
- English Alias: (R)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
- CAS Number: 110351-91-2
- Molecular Formula: C13H13NO5
- Molecular Weight: 263.25
Advantages：As a reference standard for Exatecan Impurity 4, it features a chemical structure confirmed by single-crystal X-ray diffraction and mass spectrometry, with ≥98.5% purity (HPLC), good stability at 2-8℃ in the dark, and high batch consistency. Suitable for impurity analysis of exatecan API and formulations, providing a reliable reference for quality control.
Applications：
- Impurity Detection: Used to develop HPLC methods for detecting Impurity 4 in exatecan, determining LOD and LOQ, and controlling impurity content to meet ICH Q3A standards.
- Process Optimization: Monitors the formation of Impurity 4 during exatecan synthesis, reducing its content by adjusting reaction conditions (e.g., temperature, solvent selection) to improve API purity.
- Stability Studies: Evaluates the trend of Impurity 4 in accelerated stability tests (40℃/RH75%), providing data for storage conditions and shelf life.
Background Description：Exatecan is a topoisomerase I inhibitor for cancer treatment. Impurity 4 may be generated from cyclization reactions or oxidation byproducts during synthesis, and its presence may affect drug activity and safety. Therefore, strict control of Impurity 4 is a key part of exatecan's quality system.
Research Status：
- Detection Technology: HPLC-UV with a C18 column (4.6×250mm, 5μm), mobile phase acetonitrile-0.1% phosphoric acid (45:55, v/v), detection at 254nm, with LOQ up to 0.05%.
- Formation Mechanism: Impurity 4 may originate from cyclization side reactions of intermediates or subsequent oxidation steps, and optimizing cyclizing reagent dosage and reaction time can reduce its formation.
- Safety Evaluation: Toxicological studies show the NOAEL of Impurity 4 in mice is 30mg/kg, and drug standards typically set its limit at ≤0.1%.