Carbetocin 37025-55-1 Kabitoxin
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Basic information about Carbetocin \ n \ nCarbetocin, It is CAS RN 37025-55-1 and has the molecular formula C??H??N??O??S. The molecular weight is 988.1. It also has Chinese alternative names such as Kabezuosu and Kabitoxin.
Drug Properties and Essential attributes: Cabeoxytocin is a synthetic long-acting oxytocin nine-peptide analogue with agonist properties. It is a newly synthesized analogue of oxytocin and an agonist of the oxytocin receptor. It has the permeability of the blood-brain barrier and has a longer half-life than oxytocin .
The affinity of the receptor for the oxytocin receptor is approximately 10 times lower, but its stability is significantly higher and the duration of its effect is longer. It has a higher affinity for chimeric E1 receptors, especially each combination of E1 with other extracellular domains, such as chimeric receptors E13 (Ki = 13 nM), E123 (Ki = 56 nM), and E1234 (Ki = 37 nM) .
The main use of carbetocin is mainly as an obstetric drug, used to control postpartum hemorrhage and bleeding after delivery. Specifically, it is used after selective epidural or lumbar anesthesia cesarean section to prevent uterine atony and postpartum hemorrhage.
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