NR

NR
NR
NR
NR

NR

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1 Kilogram

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Nicotinamide riboside chloride NR 23111-00-4

Quick Details

  • Appearance:White crystallization
  • Application:Anti- Virus response
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  • ProductionCapacity:1|Metric Ton|Day
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Nicotinamide riboside chloride Basic information
Product Name: Nicotinamide riboside chloride
Synonyms: Nicotinamide riboside chloride;Nicotinamide B-D Riboside Chloride(WX900111);Nicotinamide Riboside.Cl;Nicotimide riboside chloride;Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl-, chloride (1:1);3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride;3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium chloride;3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride
CAS: 23111-00-4
MF: C11H15ClN2O5
MW: 290.7
EINECS: 200-184-4
Product Categories: NMN;Food additive;API;1;23111-00-4
Mol File: 23111-00-4.mol
Nicotinamide riboside chloride Structure
 
Nicotinamide riboside chloride Chemical Properties
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Soluble to 100 mM in DMSO and to 100 mM in water
form  solid
color  White
biological source milk
Water Solubility  10mg/mL, clear, colorless
Stability: Hygroscopic

Details:

Nicotinamide riboside chloride Usage And Synthesis
Description Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
History Nicotinamide riboside (NR) was first described in 1944 as a growth factor, termed Factor V, for Haemophilus influenza, a bacterium that lives in and depends on blood. Factor V, purified from blood, was shown to exist in three forms: NAD+, NMN and NR. NR was the compound that led to the most rapid growth of this bacterium.Notably, H. influenza cannot grow on nicotinic acid, nicotinamide, tryptophan or aspartic acid, which were the previously known precursors of NAD+.
In 2000, yeast Sir2 was shown to be an NAD+-dependent protein lysine deacetylase, which led several research groups to probe yeast NAD+ metabolism for genes and enzymes that might regulate lifespan. Biosynthesis of NAD+ in yeast was thought to flow exclusively through NAMN (nicotinic acid mononucleotide).
When NAD+ synthase (glutamine-hydrolysing) was deleted from yeast cells, NR permitted yeast cells to grow. Thus, these Dartmouth College investigators proceeded to clone yeast and human nicotinamide riboside kinases and demonstrate the conversion of NR to NMN by nicotinamide riboside kinases in vitro and in vivo. They also demonstrated that NR is a natural product found in cow’s milk.
Uses Nicotinamide Riboside Chloride is a crystal form of Nicotinamide riboside (NR) chloride termed NIAGEN, generally recognized as safe (GRAS) for use in foods and in dietary supplements. Nicotinamide Riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is a newly discovered NAD (NAD+) precursor vitamin.
Uses Nicotinamide riboside is involved in nicotinate and nicotinamide metabolism. Nicotinamide riboside was originally identified as a nutrient in milk and later discovered to be a NAD(+) precursor.
Nicotinamide riboside (NR) is a naturally occurring vitamin B-3 present in the human diet that acts as an NAD+ precursor and is suggested to improve mitochondrial function and insulin sensitivity. NR acts via activation of the NAD+-dependent sirtuin enzyme family, thereby regulating oxidative metabolism. In vitro experiments of NR supplementation have shown its successful NAD+-restoring capability and subsequent increased oxidative gene expression in skeletal muscle cells. Results from in vivo mouse models have shown improvements in insulin sensitivity and oxidative energy metabolism, including enhanced metabolic flexibility, increased aerobic exercise capacity, and indications of improved mitochondrial biogenesis.

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