Varenicline tartrat...

Varenicline tartrate 375815-87-5
Varenicline tartrate 375815-87-5
Varenicline tartrate 375815-87-5
Varenicline tartrate 375815-87-5
Varenicline tartrate 375815-87-5

Varenicline tartrate 375815-87-5

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 48.0000 -58.0000
  • Min.Order :1 Kilogram
  • Purity: ≧ 99%
  • Payment Terms : D/A,D/P,T/T,Other

Keywords

10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro- VARENICLINE TARTRATE Champix

Quick Details

  • Appearance:powder
  • Application:Varenicline Tartrate (CP 526555-18) is a nicotinic AChR agonist used for the treatment of smoking addiction.
  • PackAge:In plastic outside weave or according to your request
  • ProductionCapacity:200 tons|Metric Ton|Week
  • Storage:room temp
  • Transportation:according to your request

Superiority:

Our advantages: 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,

and we have stock in there for transferring.

Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.

Details:

Molecular Formula C17H19N3O6
Molar Mass 361.34926
Melting Point 206-208°C
Boling Point 400.6°C at 760 mmHg
Flash Point 196.1°C
Solubility DMSO: >5mg/mL
Vapor Presure 1.25E-06mmHg at 25°C
Appearance powder
Color white to beige
Storage Condition room temp
In vitro study In the nAChRs-expressing HEK cells, Varenicline is a partial agonist, and the efficacy of alpha3beta4 nAChRs is 45% of the maximum efficacy of nicotine. Varenicline is a potent, partial agonist at the alpha4beta2 receptor with an EC50 of 2.3 mM and an efficacy of 13.4% (relative to acetylcholine). Varenicline has lower efficacy and higher efficacy on the alpha3beta4 receptor, EC50 is 55 mM, the efficacy is 75%.
In vivo study Varenicline stimulates [(3)H]-dopamine release from rat brain slices in vitro with significantly lower efficacy than nicotine (40-60% of nicotine), and increase the release of dopamine from the nucleus accumbens in rats, more effective than nicotine. Varenicline effectively attenuated nicotine-induced dopamine release to the level of effect of Varenicline alone, consistent with a partial agonistic effect. Varenicline reduces nicotine self-administration in rats and has a lower self-administration stop point than nicotine. Varenicline dose-dependently reduced nicotine self-administration and attenuated recovery induced by nicotine and nicotine-binding nicotine pairing cues. Varenicline, a partial agonist of alpha4beta2 nAChRs, reduces nicotine intake and was recently approved to aid smoking cessation. Varenicline selectively reduced ethanol uptake by an effective self-administered drinking regime, but did not affect sucrose uptake, in animals chronically exposed to ethanol for 2 months prior to Varenicline treatment, spontaneous ethanol consumption was also reduced, but water consumption was not affected.

 

Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,  

Our company has a number of sales team, service and information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.  

Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization,  Keep moving!  

 

 

FAQ: 
1. Are you a trade company or factory   
We are a  factory with our own trading company.  

  1. How do you control the quality   
    Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.   
  2.  How long is lead time   
    We deliver goods within 3 days for small order, 7-10 days for bulk order.   
  3.  Where is your factory located  How can I visit the factory   
     Our factory located in WEIFANG, China. It is only two hours from QINGDAO.  


6. Can i get some samples  
  Yes, we can supply free sample, but the shipping cost be paid by our customers. 


7. How to start orders or make payments  
  Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,  


8. How to confirm the Product Quality before placing orders  
  You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. 
  You can send us your product specifications and requests,we will manufacture the products according to your requests. 

9. How long is lead time

We deliver goods within 3 days for small order, 7-10 days for bulk order.

 

10. How do you treat quality complaint

  First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.

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