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tranexamic acid tranexamic acid powder tranexamic
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Tranexamic acid is a synthetic derivative of the amino acid lysine. It is used to treat or prevent excessive blood loss during surgery and in various other medical conditions. It is anantifibrinolytic that competitively inhibits the activation of plasminogen to plasmin, by binding to specific sites of both plasminogen and plasmin, a molecule responsible for the degradation of fibrin, a protein that forms the framework of blood clots. Tranexamic acid has roughly eight times theantifibrinolytic activity of an older analogue, ε aminocaproic acid.
ITEMS | STANDARDS | RESULTS |
Characteristics | White or almost white, crystalline powder | White crystalline powder |
Solubility | Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96%) | Complies |
Identification | Infrared absorption atlas consistent with the contrast atlas | Complies |
pH | 7.0~8.0 | 7.6 |
Related substances | Impurity A≤0.1% | N.D. |
Impurity B≤0.2% | 0.10% | |
Unspecified impurities≤0.1% | 0.04% | |
Sum of unspecified impurities≤0.2% | 0.04% | |
Chlorides | ≤140ppm | Complies |
Heavy metal | ≤10ppm | <10ppm |
Loss on drying | ≤0.5% | 0.18% |
Sulphated ash | ≤0.1% | 0.04% |
Assay | 99.0~101.0% | 99.70% |
Conclusion | Conforms to the BP2017 |
Function:
1.Tranexamic acid is mainly used for various types of bleeding caused by acute or chronic, localized or systemic fibrinolysis.
2. The melamine-removing effect of tranexamic acid is about 50 times higher than vitamin C and nearly 10 times that of fruit acid, so it can also be used for skin whitening.
3. Pay attention to the secondary high fibrinolysis state caused by disseminated intravascular coagulation, and use this product with caution before heparinization.
Application:
1.Post-partum bleeding: A large, international study was conducted on the use of tranexamic acid after childbirth to prevent hemorrhaging. The trial found that tranexamic acid significantly reduced the risk of death from hemorrhaging after childbirth.
2.Mouthwash for oral procedures:An antifibrinolytic mouthwash can be used for controlling bleeding after an oral procedure such as a tooth extraction. The tranexamic acid mouthwash is used prior to the procedure and immediately afterwards to prevent and reduce bleeding.
3.Nose bleeds: A topically applied tranexamic acid solution can help reduce nose bleeds.
4.Melasma: Topically applied tranexamic acid has been shown to significantly improve the appearance of melasma.
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