TU3980000 16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol USP BP EP CP
Mainly used for anti - inflammatory and anti - allergic, for rheumatoid arthritis and other collagen diseases, etc.
16alpha)-;16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet;16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione;16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2;16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione;16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien;16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione;16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol
mp | 262-264 °C(lit.) |
alpha | 75 º (c=1, dioxane) |
refractive index | 76 ° (C=1, Dioxane) |
storage temp. | 2-8°C |
solubility | ethanol: 1 mg/mL |
form | powder |
color | off-white |
Water Solubility | 10 mg/100 mL (25 ºC) |
Merck | 14,2943 |
BRN | 2066651 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive. |
CAS DataBase Reference | 50-02-2(CAS DataBase Reference) |
NIST Chemistry Reference | Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2) |
EPA Substance Registry System | Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17,21-trihydroxy- 16-methyl-, (11.beta.,16.alpha.)-(50-02-2) |
Hazard Codes | Xi,Xn,T,F |
Risk Statements | 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11 |
Safety Statements | 36/37-45-36-26-22-16 |
WGK Germany | 2 |
RTECS | TU3980000 |
Hazardous Substances Data | 50-02-2(Hazardous Substances Data) |
Chemical Properties | White Crystalline Solid |
Usage | A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase |
Usage | Dexamethasone is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthas e. |
General Description | Odorless white to off-white crystalline powder with a slightly bitter taste. |
Air & Water Reactions | Insoluble in water. |
Reactivity Profile | Dexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases. |
Fire Hazard | Flash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible. |
Biological Activity | Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. |
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