N-Methyl-N-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine

Details:

Product Name: Butenafine
Synonyms: BUTENAFINE;n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
CAS: 101828-21-1
MF: C23H27N
MW: 317.47
EINECS:
Product Categories:
Mol File: 101828-21-1.mol
Butenafine Structure
Butenafine Chemical Properties
Melting point  200-202 °C
Boiling point  426.1±14.0 °C(Predicted)
density  1.032±0.06 g/cm3(Predicted)
pka 7.87±0.50(Predicted)
CAS DataBase Reference 101828-21-1(CAS DataBase Reference)
Safety Information
MSDS Information
Butenafine Usage And Synthesis
Uses Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.
Butenafine (Mentax)
Definition ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
Brand name Lotrimin (Schering); Mentax (Mylan Bertek).