Nifekalant hydrochloride

Details:

Product Name: Nifekalant hydrochloride
Synonyms: ms551;NIFEKALANT HYDROCHLORIDE;Nifekalant 130636-43-0 /;1,3-Dimethyl-6-[2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1H,3H)-pyrimidinedione hydrochloride;1,3-Dimethyl-6-((2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino)-2,4(1H),3H)-pyrimidinedione HCl;NIFEKALANT HCL;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride;2,4(1H,3H)-Pyrimidinedione, 6-((2-((2-hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-, monohydrochloride
CAS: 130656-51-8
MF: C19H28ClN5O5
MW: 441.91
EINECS: 1533716-785-6
Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File: 130656-51-8.mol
Nifekalant hydrochloride Structure
Nifekalant hydrochloride Chemical Properties
Melting point  172-174°
pka 7.05(at 25℃)
CAS DataBase Reference 130656-51-8(CAS DataBase Reference)
Safety Information
MSDS Information
Nifekalant hydrochloride Usage And Synthesis
Description Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.
Chemical Properties Yellow Solid
Originator Mitsui (Japan)
Uses Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
Brand name Shinbit