CasNo.58-14-0,Pyrimethamine,(58-14-0) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 99.0%Min
Payment Terms : L/C,T/T,

Keywords

Pyrimethamine 58-14-0 C12H13ClN4

Quick Details

Appearance:conform
Application:For pharmacy
PackAge:according to the demand of cusotmer
ProductionCapacity:1|Metric Ton|Day
Storage:Room Temperature
Transportation:shipped

Superiority:

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Customs Synthesis

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1. Higest quality and good package

2.Fast delivery

3.Better payment term

4.Fast response to customer within 6 hours

5.Good business credit in Europe ,US ,Japan ,Korea

Anyway ,if you need any chemicals from China ,Henan Tianfu can help you

Details:

Pyrimethamine Basic information

Product Name:	Pyrimethamine
Synonyms:	2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine, 5-(p-chlorophenyl)-6-ethyl-;2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;4753 R.P.;4753r.p.;5-(4’-chlorophenyl)-2,4-diamino-6-ethylpyrimidine
CAS:	58-14-0
MF:	C12H13ClN4
MW:	248.71
EINECS:	200-364-2
Product Categories:	APIs & Intermediate;Pyrimidine;Organics;Amines;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Inhibitor;Heterocycle-Pyrimidine series;DARAPRIM
Mol File:	58-14-0.mol

Pyrimethamine Chemical Properties

mp	233-234°C
storage temp.	0-6°C
Water Solubility	<0.01 g/100 mL at 21 ºC
Stability:	Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	58-14-0(CAS DataBase Reference)
NIST Chemistry Reference	Pyrimethamine(58-14-0)
EPA Substance Registry System	2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl- (58-14-0)

Safety Information

Hazard Codes	Xn
Risk Statements	22
RIDADR	3249
WGK Germany	3
RTECS	UV8140000
HazardClass	6.1(b)
PackingGroup	III

MSDS Information

Provider	Language
2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine	English
SigmaAldrich	English

Pyrimethamine Usage And Synthesis

Chemical Properties	White Solid
Usage	Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial
Usage	For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
General Description	Odorless white crystalline powder. Tasteless. An antimalarial drug.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Pyrimethamine is sensitive to exposure to light . Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard	Flash point data for Pyrimethamine are not available; however, Pyrimethamine is probably combustible.
Biological Activity	Potent inhibitor of multi-drug and toxin extrusion (MATE) transporters (K i values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR).