21829-25-4 Nifedipine C17H18N2O6
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Nifedipine Basic information |
Product Name: | Nifedipine |
Synonyms: | 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddime;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester;4-(2’-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethy;5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-dim;Adalat CC;bay1040;corinfar;Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate |
CAS: | 21829-25-4 |
MF: | C17H18N2O6 |
MW: | 346.34 |
EINECS: | 244-598-3 |
Product Categories: | Pharmaceutical;Active Pharmaceutical Ingredients;Dihydropyridine Class Chemicals;Functional Materials;Photopolymerization Initiators;Intermediates & Fine Chemicals;Pharmaceuticals;Calcium channel;Ion Channels;Dihydropyridine;Pharmaceutical intermediate;Isotopically Labeled Pharmaceutical Reference Standard;CAPOTEN;Cardiovascular APIs;Cardiovascular Drugs |
Mol File: | 21829-25-4.mol |
Nifedipine Chemical Properties |
mp | 171-175 °C |
storage temp. | 2-8°C |
solubility | DMSO: soluble |
form | powder |
color | yellow |
Water Solubility | <0.1 g/100 mL at 19.5 ºC |
Merck | 6528 |
CAS DataBase Reference | 21829-25-4(CAS DataBase Reference) |
NIST Chemistry Reference | Nifedipine(21829-25-4) |
EPA Substance Registry System | 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-( 2-nitrophenyl)-, dimethyl ester(21829-25-4) |
Safety Information |
Hazard Codes | Xn,Xi |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 1 |
RTECS | US7975000 |
HazardClass | IRRITANT |
MSDS Information |
Provider | Language |
---|---|
Nifedipine | English |
SigmaAldrich | English |
ACROS | English |
Nifedipine Usage And Synthesis |
Chemical Properties | Yellow Crystalline Solid |
Usage | Used as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker |
Usage | For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents). |
General Description | Odorless yellow crystals or powder. Tasteless. |
Air & Water Reactions | Aqueous solutions are very sensitive to light. . Insoluble in water. |
Reactivity Profile | Nifedipine is sensitive to light. |
Fire Hazard | Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible. |
Biological Activity | L-type calcium channel blocker. |
Nifedipine Preparation Products And Raw materials |
Raw materials | Ethyl cyanoacetate-->Diethyl oxalate-->Benzaldehyde-->2-Nitrotoluene-->Methyl acetoacetate-->2-Nitrobenzaldehyde-->4-Aminobenzaldehyde |
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